Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp MY-42

Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC50 6.7 mu M value for 2 and 9.8 mu M for 3). (C) 2011 Elsevier Ltd. All rights reserved.