期刊
PHYTOCHEMISTRY
卷 72, 期 9, 页码 909-915出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.03.003
关键词
Ziziphus mauritiana; Rhamnaceae; Cyclopeptide alkaloid; Mauritines L and M; Antiplasmodial activity; Antimycobacterial activity
资金
- Strategic Basic Research Grant of The Thailand Research Fund
- Center of Excellent for Innovation in Chemistry (PERCH-CIC)
- Commission on Higher Education
- Srinakharinwirot University
Investigation of the MeOH extract obtained from the root of the Ziziphus mauritiana grown in Thailand resulted in the isolation of two 14- and 13-membered cyclic alkaloids, mauritine L (1) and mauritine M (2), and three known cyclopeptide alkaloids, nummularines H (3), B (4) and hemsine A(S). Their structures were elucidated on the basis of extensive NMR spectroscopic analysis. The first single crystal X-ray diffraction study of the 13-membered ring cyclopeptide, nummularine B methiodide (4'), revealed all S configurations on the amino acid residues. The isolated alkaloids exhibited potent antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC(50)) ranging from 3.7 to 10.3 mu M. Compounds 2 and 3 also demonstrated antimycobacterial activity against Mycobacterium tuberculosis with the MIC of 72.8 and 4.5 mu M, respectively. (C) 2011 Elsevier Ltd. All rights reserved.
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