期刊
PHYTOCHEMISTRY
卷 71, 期 17-18, 页码 2168-2173出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.09.008
关键词
Cordia sebestena; Boraginaceae; Phenylpropaniods; BACE1
资金
- Victoria S and Bradley L Geist Foundation [20070461]
- Alzheimer s Association [NIRG-08-90880]
- Alzheimer s Drug Discovery Foundation [281204]
- National Institute of Aging [R20072671]
- National Science Foundation [CH E9974921]
- Elsa Pardee Foundation
- Department of Defense [W911NF-04-1-0344]
Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4) Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1 (C) 2010 Elsevier Ltd All rights reserved
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