Cytotoxic tirucallaneC(26) triterpenoids from the stem barks of Aphanamixis grandifolia

Five tirucallane type C-26 triterpenoids accompanied by two known compounds 3 alpha-hydroxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone and 3-oxo-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone were isolated from the stem barks of Aphanamixis grandifolia Their structures were established mainly by means of a combination of 1D and 2D NMR spectroscopic and mass spectrometry techniques as 3 alpha-hydroxyl-21 alpha-methoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone 3 alpha-hydroxy-21 beta-methoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone 3-oxo-21 alpha-methoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone 3-oxo-21 beta-methoxy-24 25 26 27-tetranortirucall-7-ene-23 (21)-lactone and 3-oxo-21 alpha-ethoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone All Isolates were in vitro evaluated for their cytotoxic activities against five tumor cell lines (MCF-7 HeLa HepG2 SGC-7901 and BGC-823) (C) 2010 Elsevier Ltd All rights reserved