期刊
PHYTOCHEMISTRY
卷 71, 期 1, 页码 95-99出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.09.027
关键词
Terminalia tropophylla; Combretaceae; Saponins; Lignan; NMR; Antiproliferative activity
资金
- Fogarty International Center
- National Cancer Institute
- National Science Foundation
- National Heart, Lung and Blood Institute
- National Institute of Mental Health
- Office of Dietary Supplements
- Office of the Director of NIH [U01 TW000313]
- FOGARTY INTERNATIONAL CENTER [U01TW000313] Funding Source: NIH RePORTER
A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to isolation of the oleanane-type triterpenoid saponin 1, the lignan derivative 2, and the two known saponins arjunglucoside 1 (3) and sericoside (4). The structures of compounds 1 (terminaliaside A) and 2 (4'-O-cinnamoyl cleomiscosin A) were elucidated using 1 D and 2D NMR experiments and mass spectrometry. Compound 1 showed antiproliferative activity against the A2780 human ovarian cancer cell line with an IC50 value of 1.2 mu M. (C) 2009 Elsevier Ltd. All rights reserved.
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