期刊
PHYTOCHEMISTRY
卷 70, 期 1, 页码 128-132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.10.017
关键词
Aspergillus terreus; Marine natural products; Butenolides; Butyrolactone I; Aspernolides
资金
- Ministry of Earth Sciences (MoES), New Delhi
Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone 1, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone 1, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据