期刊
PHYTOCHEMISTRY
卷 70, 期 2, 页码 198-206出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.12.001
关键词
Corydalis platycarpa; Fumariaceae; Macleaya cordata; Papaveraceae; Nandina domestica; Berberidaceae; O-Methylation; Cell cultures; Optical purity; Chiral LC-MS; Chiral LC-CD; 1-Benzyl-N-methyltetrahydroisoquinolines
Effective enantiomeric separations of 1-benzyl-N-methyltetrahydroisoquinolines were achieved using commercially available Chiralcel OD-H and OJ-H columns. Online LC-CD analysis allowed for the establishment of a correlation between the absolute configuration of the separated enantiomers and their characteristic CD transitions. LC-MS combined with LC-CD analysis permitted chiral purity determinations of O-methylated metabolites of nine phenolic 1-benzyl-N-methyltetrahydroisoquinolines in cell cultures of Corydalis, Macleaya, and Nandina species. (C) 2008 Elsevier Ltd. All rights reserved.
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