期刊
PHYTOCHEMISTRY
卷 70, 期 2, 页码 237-243出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.11.010
关键词
Alpinia galanga; Zingiberaceae; Kha (Thailand); Osteoarthritis; Phenolic compound; p-Hydroxycinnamaldehyde
资金
- Thailand Research Fund [BRG 4780018]
- Royal Golden jubilee Ph.D. Program [PHD/0155/2548, PHD/0183/2547]
- Graduate School of Chiang Mai University
- National Research Council of Thailand
Osteoarthritis (CA) is the most common form of arthritis and affects millions of people worldwide. Patients have traditionally been treated with non-steroidal anti-inflammatory drugs (NSAIDs), but these are associated with significant side effects. Purification of the acetone extract of Alpinia galanga afforded p-hydroxycinnamaldehyde, as identified by nuclear magnetic resonance and mass spectrometry analyses. By exploiting the cartilage explant culture, p-hydroxycinnamaidehyde suppressed loss of uronic acid, resulting in release of hyaluronan (HA), sulfated glycosaminoglycans (s-GAGs) and matrix metalloproteinases (MMPs). p-Hydroxycinnamaldehyde and interleukin-1 beta (IL-1 beta), when incubated in primary human chondrocytes, also reduced release of HA, s-GAG and MMP-2. The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased. This study shows that p-hydroxycinnaldehyde from A. galanga Linn. is a potential therapeutic agent for treatment of OA. (C) 2008 Elsevier Ltd. All rights reserved.
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