期刊
PHYTOCHEMISTRY
卷 70, 期 3, 页码 407-413出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.01.007
关键词
Corynespora cassiicola; Endophytic fungi; Depsidone; Diaryl ether; Aromatase inhibitor; Radical scavenging; Antioxidant activity; Cytotoxic activity
资金
- Thailand Research Fund [DBG5180014]
- Center for Environmental Health, Toxicology and Management of Chemicals (ETM)
- Mahidol University
- Commission on Higher Education
Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50 value of 5.30 mu M. (C) 2009 Elsevier Ltd. All rights reserved.
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