期刊
PHYTOCHEMISTRY
卷 69, 期 17, 页码 2979-2983出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.09.019
关键词
Ferula elaeochytris; Apiaceae; Sesquiterpene; Leukemia; Dasatinib; Imatinib
Phytochemical investigation of the roots of Ferula elaeochytris made it possible to isolate two sesquiterpene esters, 6-anthraniloyljaeschkeanadiol (elaeochytrin A) and 4 beta-hydroxy-6 alpha-(p-hydroxybenzoyloxy)dauc-9-ene (elaeochytrin B), as well as eight known compounds: 6-angeloyljaeschkeanadiol, teferidin, ferutinin, 6-(p-hydroxybenzoyl)epoxyjaeschkeanadiol, 6-(p-hydroxybenzoyl)lancerotriol, 5-caffeoylquinic acid, 1,5-dicaffeoylquinic acid and sandrosaponin IX. The cytotoxic activities of all compounds were investigated on K562R (imatinib-resistant) human chronic myeloid leukaemia and DA1-3b/M2(BCR-ABL) (dasatinib-resistant) mouse leukemia cell line. Elaeochytrin A was the most active compound on both cell lines (IC50 = 12.4 and 7.8 mu M, respectively). It was also tested on non-resistant human promyelocytic leukemia cells (HL60, IC50 = 13.1 mu M) and was not toxic to normal peripheral blood mononuclear cells up to 100 mu M. (C) 2008 Elsevier Ltd. All rights reserved.
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