A-seco-oleane-type triterpenes from Phomopsis sp (strain HK10458) isolated from the mangrove plant Hibiscus tiliaceus

From the fermentation broth of an unidentified Phomopsis sp. (strain HK10458) isolated from the mangrove plant Hibiscus tiliaceus, four A-seco-oleane-type triterpenes, namely 3,4-seco-olean-11,13-dien-4,15 alpha, 22 beta,24-tetraol-3-oic acid (1), 3,4-seco-olean-11,13-dien4,7 beta,22 beta,24-tetraol-3-oic acid (2), 3,4-seco- olean-13-en-4,7,15,22,24-pentaol-3-oic acid (3), and 3,4-seco-olean-13-en-4,15,22,24-tetraol3-oic acid (4) were obtained. Their structures were elucidated by extensive spectroscopic (UV, IR, FABMS, and 2D NMR) data analyses. (C) 2007 Elsevier Ltd. All rights reserved.