期刊
PHYTOCHEMICAL ANALYSIS
卷 21, 期 6, 页码 590-596出版社
WILEY
DOI: 10.1002/pca.1239
关键词
herbal medicine; trace metals; speciation analysis; bioavailability; risk assessment
资金
- National Natural Science Foundation of China [20775067, 20705031, 20805041]
- Science and Technology Committee of Fujian Province, China [2008F5063]
- Program for New Century Excellent Talents in Fujian Province University [200720]
Sample preparation is the first crucial step in the speciation analysis, bioavailability and risk assessment of trace metals in plant samples such as herb and vegetables. Two bionic technologies titled 'in vitro digestion' and 'extraction with biomembrane' were developed for pre-treatment of herbal decoction. The decoctions of Aconiteum carmichaeli and Paeonia lactifiora were digested at body temperature, at the acidity of the stomach or intestine and with inorganic and organic materials (digestive enzymes were included for whole-bionic and excluded for semi-bionic) found in the stomach or intestine. Being similar to the biomembrane between the gastrointestinal tract and blood vessels, monolayer liposome was used as a biomembrane model. Affinity-monolayer liposome metals and water-soluble metals were used for speciation analysis and bioavailability assessment of copper and zinc in herbal decoction. In the decoction of Aconiteum carmichaeli and Paeonia lactifiora, Zn was mainly absorbed in the intestine and Cu was mainly absorbed by both stomach and intestine. The safe dosage for males and females is below 257.1 g/day Aconiteum carmichaeli and 529.4 g/day Paeonia lactifiora. Copyright (C) 2010 John Wiley & Sons, Ltd.
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