期刊
PHYSIOLOGY & BEHAVIOR
卷 100, 期 5, 页码 525-534出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2010.03.018
关键词
Angiotensin; Renin; Obesity; Diabetes; Adipose; Food intake
资金
- NHLBI NIH HHS [K99 HL096830-01, R00 HL096830, K99 HL096830] Funding Source: Medline
- NIDDK NIH HHS [R01 DK078201-03, R01 DK078201] Funding Source: Medline
- NINDS NIH HHS [F31 NS068122, F31 NS068122-01] Funding Source: Medline
The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic syndrome. It may serve as a causal link among obesity and several co-morbidities. Drugs that reduce the synthesis or action of angiotensin-II (A-II; the primary effector peptide of the RAS) have been used to treat hypertension for decades and, more recently, clinical trials have determined the utility of these pharmacological agents to prevent insulin resistance. Moreover, there is evidence that the RAS contributes to body weight regulation by acting in various tissues. This review summarizes what is known of the actions of the RAS in the brain and throughout the body to influence various metabolic disorders. Special emphasis is given to the role of the RAS in body weight regulation. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. (C) 2010 Elsevier Inc. All rights reserved.
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