期刊
PHYSIOLOGY & BEHAVIOR
卷 96, 期 1, 页码 155-161出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2008.09.024
关键词
Acupuncture; Cerebral multi-infarction; Morris water maze (MWM); Apoptosis; Bcl-2; Bax; Hippocampus
资金
- National Natural Science Foundation of China [30630074, 30772839, 30801483]
- Tianjin Natural Science Fund [07JCZDJC08800, 08JCZDJC15800]
- Science and Technology Research of Ministry of Education of the People's Republic of China [207006]
- China Postdoctoral Science Foundation [20070420024]
- college in Tianjin city [20060306]
Vascular dementia (VaD) is the second most common cause of dementia in the world today. In this paper, we observed the effect of acupuncture oil memory impairment, apoptosis and expression of Bcl-2 and Bax in hippocampus of cerebral multi-infarction rats. The results indicated that acupuncture significantly improved memory impairment induced by cerebral multi-infarction, as evaluated by shortened escape latency and increased swimming time in the target quadrant. Meanwhile, based oil the observation in hippocampal CA1 region through methods of the terminal deoxynucleotidyl transferase nick end labeling (TUNEL). immunohistochemistry and in situ hybridization, acupuncture decreased the number of apoptotic cells and expression of the proapoptotic Bax gene, on the contrary, it increased expression of the antiapoptotic gene Bcl-2. The result of the research suggested that acupuncture can exert antiapoptotic effect through counter-regulating Bcl-2 and Bax gene expression. (C) 2008 Elsevier Inc. All rights reserved.
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