期刊
PHYSIOLOGY
卷 29, 期 4, 页码 286-298出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00001.2014
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资金
- National Institute of Child Health and Human Development [U54 HD-029990, R01 HD-056034]
- Hong Kong General Research Fund [HKBU 261812]
Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events.
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