期刊
PHYSIOLOGY
卷 29, 期 6, 页码 413-420出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00029.2014
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Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.
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