期刊
PHYSIOLOGY
卷 29, 期 6, 页码 446-455出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00012.2014
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资金
- National Heart, Lung, and Blood Institute Grant [HL-034555]
- Schuchtermann-Foundation (Germany, Dortmund)
The adequate and efficient functioning of the microcirculation requires not only numerous vessels providing a large surface area for transport but also a structure that provides short diffusion distances from capillaries to tissue and efficient distribution of convective blood flow. Theoretical models show how a combination of angiogenesis, remodeling, and pruning in response to hemodynamic and metabolic stimuli, termed angioadaptation, generates well organized, functional networks.
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