The Athlete's Heart vs. the Failing Heart: Can Signaling Explain the Two Distinct Outcomes?

Cardiac remodeling is typically associated with disease and can lead to heart failure. In contrast, remodeling that occurs in the athlete's heart is considered an adaptive physiological response. This review provides an overview of signaling mechanisms responsible for inducing left ventricular hypertrophy in the athlete's heart and in settings of pathological hypertrophy and heart failure.