期刊
PHYSIOLOGY
卷 25, 期 1, 页码 8-15出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00038.2009
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类别
资金
- National Eye Institute [EY-09339, EY-019050]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK-007319]
Photoreceptor cells maintain a roughly constant length by continuously generating new outer segments from their base while simultaneously releasing mature outer segments engulfed by the retinal pigment epithelium (RPE). Thus post-mitotic RPE cells phagocytose an immense amount of material over a lifetime, disposing of photoreceptor cell waste while retaining useful content. This review focuses on current knowledge of outer segment phagocytosis, discussing the steps involved along with their critical participants as well as how various perturbations in outer segment ( OS) disposal can lead to retinopathies.
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