期刊
PHYSIOLOGY
卷 23, 期 4, 页码 205-211出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00008.2008
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资金
- NHLBI NIH HHS [R01 HL067963-05, R01 HL067963, P01 HL036573-200011, P01 HL036573, HL-36573, HL-67963] Funding Source: Medline
- NIGMS NIH HHS [R01 GM078565-02, GM-78565, R01 GM078565] Funding Source: Medline
The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na(+). This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.
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