期刊
PHYSIOLOGY
卷 23, 期 6, 页码 313-321出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00025.2008
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资金
- NIMH NIH HHS [U19 MH082441] Funding Source: Medline
Different families of G-protein-coupled receptors (GPCRs) have been engineered to provide exclusive control over the activation of these receptors and thus to understand better the consequences of their signaling in vitro and in vivo. These engineered receptors, named RASSLs (receptors activated solely by synthetic ligands) and DREADDs (designer receptors exclusively activated by designer drugs), are insensitive to their endogenous ligands but can be activated by synthetic drug-like compounds. Currently, the existing RASSLs and DREADDs cover the G(i), G(q), and G(s) signaling pathways. These modified GPCRs can be utilized as ideal tools to study GPCR functions selectively in specific cellular populations.
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