期刊
PHYSIOLOGICAL REVIEWS
卷 94, 期 1, 页码 235-263出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00018.2013
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资金
- Agence Nationale de la Recherche [ANR-08-BLAN-0012-12, ANR-09-BLAN-283, ANR-12-BSV5-0014]
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV5-0014] Funding Source: Agence Nationale de la Recherche (ANR)
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton drives a large range of cellular processes including polarity establishment, morphogenesis, and motility. This is possible because actin filaments are semi-flexible polymers that, in conjunction with the molecular motor myosin, can act as biological active springs or dashpots (in laymen's terms, shock absorbers or fluidizers) able to exert or resist against force in a cellular environment. To modulate their mechanical properties, actin filaments can organize into a variety of architectures generating a diversity of cellular organizations including branched or crosslinked networks in the lamellipodium, parallel bundles in filopodia, and antiparallel structures in contractile fibers. In this review we describe the feedback loop between biochemical and mechanical properties of actin organization at the molecular level in vitro, then we integrate this knowledge into our current understanding of cellular actin organization and its physiological roles.
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