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Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells
Peter J. Wen et al.
NATURE COMMUNICATIONS (2011)
High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
Lydia W. T. Cheung et al.
CANCER DISCOVERY (2011)
Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity
Jia Xie et al.
SCIENTIFIC REPORTS (2011)
A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis
Marcus J. Taylor et al.
PLOS BIOLOGY (2011)
Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J
Guy M. Lenk et al.
PLOS GENETICS (2011)
Anchors for effectors: subversion of phosphoinositide lipids by Legionella
Hubert Hilbi et al.
FRONTIERS IN MICROBIOLOGY (2011)
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
M. Christine Hollander et al.
NATURE REVIEWS CANCER (2011)
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis
Sandra Romero-Suarez et al.
AGING-US (2010)
Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease
Yasuo To et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)
Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment
Erica L. Martin et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)
Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity
Kristen F. Swaney et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 39 (2010)
Regulation of PIKfyve phosphorylation by insulin and osmotic stress
Elaine V. Hill et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform
Minchuan Wang et al.
BIOCHEMICAL JOURNAL (2010)
PIP4K beta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4K alpha
Yvette Bultsma et al.
BIOCHEMICAL JOURNAL (2010)
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry
Ciara M. Walsh et al.
BIOCHEMICAL JOURNAL (2010)
ADF/Cofilin Binds Phosphoinositides in a Multivalent Manner to Act as a PIP2-Density Sensor
Hongxia Zhao et al.
BIOPHYSICAL JOURNAL (2010)
PI3K/p110δ is a novel therapeutic target in multiple myeloma
Hiroshi Ikeda et al.
BLOOD (2010)
Lyn- and PLC-β3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
Wenbin Xiao et al.
BLOOD (2010)
Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
Valerie Martin et al.
BLOOD (2010)
PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking
Ankush Vaid et al.
BLOOD (2010)
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
Sarah E. M. Herman et al.
BLOOD (2010)
Mtmr8 is essential for vasculature development in zebrafish embryos
Jie Mei et al.
BMC DEVELOPMENTAL BIOLOGY (2010)
A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression
David Kerk et al.
BMC EVOLUTIONARY BIOLOGY (2010)
A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis
Nicola J. Beresford et al.
BMC GENOMICS (2010)
The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
Cullen M. Taniguchi et al.
CANCER RESEARCH (2010)
Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids
Katarina Moravcevic et al.
CELL (2010)
Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication
Nai-Yun Hsu et al.
CELL (2010)
Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
Dale W. Hailey et al.
CELL (2010)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
Signaling From the Golgi: Mechanisms and Models for Golgi Phosphoprotein 3-Mediated Oncogenesis
Kenneth L. Scott et al.
CLINICAL CANCER RESEARCH (2010)
Mammalian diseases of phosphatidylinositol transfer proteins and their homologs
Aaron H. Nile et al.
CLINICAL LIPIDOLOGY (2010)
Activation of TRP Channels by Protons and Phosphoinositide Depletion in Drosophila Photoreceptors
Jiehong Huang et al.
CURRENT BIOLOGY (2010)
Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector
Finly Philip et al.
CURRENT BIOLOGY (2010)
Manipulation of host membrane machinery by bacterial pathogens
Pascale Cossart et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Inositol phosphate synthesis and the nuclear processes they affect
Jessica P. Monserrate et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis
Mark T. Howes et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Cell biology of Ca2+-triggered exocytosis
Zhiping P. Pang et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Targeting the PI3K signaling pathway in cancer
Kwok-Kin Wong et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2010)
Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p
Emi Mizuno-Yamasaki et al.
DEVELOPMENTAL CELL (2010)
Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA
Hye-Young Suh et al.
EMBO JOURNAL (2010)
Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function
Andrew Manford et al.
EMBO JOURNAL (2010)
Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains
Marc Lenoir et al.
EMBO REPORTS (2010)
Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast
Lina Tawk et al.
EUKARYOTIC CELL (2010)
Biophysical characterization of the fluorescent protein voltage probe VSFP2.3 based on the voltage-sensing domain of Ci-VSP
Alicia Lundby et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2010)
Interaction between Sec7p and Pik1p: The first clue for the regulation of a coincidence detection signal
Yvonne Gloor et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2010)
Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway
Eric S. White et al.
EXPERIMENTAL CELL RESEARCH (2010)
Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
Barbara Leibiger et al.
FASEB JOURNAL (2010)
Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1
Yiming Chang et al.
FEBS LETTERS (2010)
The role of PI3P phosphatases in the regulation of autophagy
Isabelle Vergne et al.
FEBS LETTERS (2010)
Mucolipins: Intracellular TRPML1-3 channels
Xiping Cheng et al.
FEBS LETTERS (2010)
Phospholipase C-eta2 is highly expressed in the habenula and retina
Kaori Kanemaru et al.
GENE EXPRESSION PATTERNS (2010)
Zebrafish MTMR14 is required for excitation-contraction coupling, developmental motor function and the regulation of autophagy
J. J. Dowling et al.
HUMAN MOLECULAR GENETICS (2010)
Tetraspanin CD81 Is Required for Listeria monocytogenes Invasion
To Nam Tham et al.
INFECTION AND IMMUNITY (2010)
Multiple Host Proteins That Function in Phosphatidylinositol-4-Phosphate Metabolism Are Recruited to the Chlamydial Inclusion
Andrew M. Moorhead et al.
INFECTION AND IMMUNITY (2010)
A role for phosphoinositol 3-kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
John A. Marwick et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)
Differential Regulation of Phospholipase C-β2 Activity and Membrane Interaction by Gαq, Gβ1γ2, and Rac2
Orit Gutman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
Ghada A. Soliman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes
Junjing Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress
Helene Maccario et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A Key Role for the Phosphorylation of Ser440 by the Cyclic AMP-dependent Protein Kinase in Regulating the Activity of the Src Homology 2 Domain-containing Inositol 5′-Phosphatase (SHIP1)
Jun Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2
Helena A. Walz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
ArPIKfyve Regulates Sac3 Protein Abundance and Turnover DISRUPTION OF THE MECHANISM BY Sac3I41T MUTATION CAUSING CHARCOT-MARIE-TOOTH 4J DISORDER
Ognian C. Ikonomov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility via Activation of the Ryanodine Receptor
Chad D. Touchberry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Stress-induced Synthesis of Phosphatidylinositol 3-Phosphate in Mycobacteria
Yasu S. Morita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony
Kathryn G. Foster et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain
Laura A. Volpicelli-Daley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes
Aurelie Gresset et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Control of mRNA Export and Translation Termination by Inositol Hexakisphosphate Requires Specific Interaction with Gle1
Abel R. Alcazar-Roman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes
Michal Bohdanowicz et al.
JOURNAL OF CELL BIOLOGY (2010)
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
Fubito Nakatsu et al.
JOURNAL OF CELL BIOLOGY (2010)
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis
Huaqing Cai et al.
JOURNAL OF CELL BIOLOGY (2010)
The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy
Zhixun Dou et al.
JOURNAL OF CELL BIOLOGY (2010)
Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions
Michaella Velichkova et al.
JOURNAL OF CELL BIOLOGY (2010)
Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPβ is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum
Nicolas Carvou et al.
JOURNAL OF CELL SCIENCE (2010)
Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics
Jonathan R. Halstead et al.
JOURNAL OF CELL SCIENCE (2010)
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes
Monica J. Naughtin et al.
JOURNAL OF CELL SCIENCE (2010)
PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation
Laure Plantard et al.
JOURNAL OF CELL SCIENCE (2010)
Activation and regulation of store-operated calcium entry
Jeremy T. Smyth et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells
Bjoern H. Falkenburger et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells
Bjoern H. Falkenburger et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
SHIP Is Required for Dendritic Cell Maturation
Frann Antignano et al.
JOURNAL OF IMMUNOLOGY (2010)
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIα at the trans-Golgi network
Shane Minogue et al.
JOURNAL OF LIPID RESEARCH (2010)
Phosphatidylinositol-4,5-bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization
Aurelie Bertin et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Ca2+-Dependent Desensitization of TRPV2 Channels Is Mediated by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate
Jose Mercado et al.
JOURNAL OF NEUROSCIENCE (2010)
Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes
Min Ju et al.
JOURNAL OF PHYSIOLOGY-LONDON (2010)
Complementation of Saccharomyces cerevisiae pik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum
Tim Krueger et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2010)
Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C
Simge Akbulut et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility
Elisa Ciraolo et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
A Cdc42 Activation Cycle Coordinated by PI 3-Kinase during Fc Receptor-mediated Phagocytosis
Peter Beemiller et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα
Sangeeta Banerji et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain
Yoshiyuki Soeda et al.
MOLECULAR ENDOCRINOLOGY (2010)
Multivariate analysis of male reproductive function in Inpp5b-/- mice reveals heterogeneity in defects in fertility, sperm-egg membrane interaction and proteolytic cleavage of sperm ADAMs
Matthew R. Marcello et al.
MOLECULAR HUMAN REPRODUCTION (2010)
Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids
Motohiro Tani et al.
MOLECULAR MICROBIOLOGY (2010)
The Small GTPase Ral Couples the Angiotensin II Type 1 Receptor to the Activation of Phospholipase C-δ1
Christina M. Godin et al.
MOLECULAR PHARMACOLOGY (2010)
Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors
Mohamed Aittaleb et al.
MOLECULAR PHARMACOLOGY (2010)
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae
Oriol Gallego et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
Orm family proteins mediate sphingolipid homeostasis
David K. Breslow et al.
NATURE (2010)
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
Junko Sasaki et al.
NATURE (2010)
The origin of the autophagosomal membrane
Sharon A. Tooze et al.
NATURE CELL BIOLOGY (2010)
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP
Susy C. Kohout et al.
NATURE CHEMICAL BIOLOGY (2010)
The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Alex Berndt et al.
NATURE CHEMICAL BIOLOGY (2010)
Subtle variations in Pten dose determine cancer susceptibility
Andrea Alimonti et al.
NATURE GENETICS (2010)
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
Christian C. Abnet et al.
NATURE GENETICS (2010)
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
Kristin L. Arendt et al.
NATURE NEUROSCIENCE (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Non-vesicular lipid transport by lipid-transfer proteins and beyond
Sima Lev
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
PKC and the control of localized signal dynamics
Carine Rosse et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
Ok-Ho Shin et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate
Byung-Chang Suh et al.
NEURON (2010)
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN
L. Davidson et al.
ONCOGENE (2010)
Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides
Juha Saarikangas et al.
PHYSIOLOGICAL REVIEWS (2010)
Phospholipase C Gamma 2 Is Critical for Development of a Murine Model of Inflammatory Arthritis by Affecting Actin Dynamics in Dendritic Cells
Viviana Cremasco et al.
PLOS ONE (2010)
The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression
Marie-Josee Langlois et al.
PLOS ONE (2010)
The Biphasic Increase of PIP2 in the Fertilized Eggs of Starfish: New Roles in Actin Polymerization and Ca2+ Signaling
Jong T. Chun et al.
PLOS ONE (2010)
Channelopathies linked to plasma membrane phosphoinositides
Diomedes E. Logothetis et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)
Phosphoinositide-binding interface proteins involved in shaping cell membranes
Tadaomi Takenawa
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2010)
Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum
Pingbo Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase
Hashem A. Dbouk et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
Clare G. Fedele et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers
Alan H. Beggs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling
Zsofia Szentpetery et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA
Yongqun Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair
Amit Kumar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase
Ryaz B. Chagpar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
Sang Hyun Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34
Simon Miller et al.
SCIENCE (2010)
Kinetic Scaffolding Mediated by a Phospholipase C-β and Gq Signaling Complex
Gary L. Waldo et al.
SCIENCE (2010)
A Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity
Christopher A. Broberg et al.
SCIENCE (2010)
SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting
Jan R. T. van Weering et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2010)
Zebrafish Class 1 Phosphatidylinositol Transfer Proteins: PITPβ and Double Cone Cell Outer Segment Integrity in Retina
Kristina E. Ile et al.
TRAFFIC (2010)
The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling
Vytas A. Bankaitis et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
IP3 Receptors: Toward Understanding Their Activation
Colin W. Taylor et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
ITAM-mediated Signaling by the T-Cell Antigen Receptor
Paul E. Love et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
T-Cell Signaling Regulated by the Tec Family Kinase, Itk
Amy H. Andreotti et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Identification and Characterization of Novel Inhibitors of mPTPB, an Essential Virulent Phosphatase from Mycobacterium tuberculosis
Lan Chen et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Xian-ping Dong et al.
NATURE COMMUNICATIONS (2010)
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer
Yue Sun et al.
BREAST CANCER RESEARCH (2010)
OCRL1 function in renal epithelial membrane traffic
Shanshan Cui et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
Deleterious Variants of FIG4. a Phosphoinositide Phosphatase, in Patients with ALS
Clement Y. Chow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Association of the PIK4CA Schizophrenia-Susceptibility Gene in Adults With the 22q11.2 Deletion Syndrome
Jacob A. S. Vorstman et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2009)
Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1α in Jurkat T cells
Yuichiro Matsushita et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Mechanisms of Endocytosis
Gary J. Doherty et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
The p85 beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells
Jean S. Oak et al.
AUTOIMMUNITY (2009)
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes
Ognian C. Ikonomov et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Two novel phosphatidylinositol-4-phosphate 5-kinase type Iγ splice variants expressed in human cells display distinctive cellular targeting
Nicholas J. Schill et al.
BIOCHEMICAL JOURNAL (2009)
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
Pamela J. Plant et al.
BIOCHEMICAL JOURNAL (2009)
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P2
Gerald R. V. Hammond et al.
BIOCHEMICAL JOURNAL (2009)
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PlKfyve underPPIn endo-lysosome function
Stephen K. Dove et al.
BIOCHEMICAL JOURNAL (2009)
Investigation of the H+-myo-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling
Elena Di Daniel et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
Yu-Yun Chang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia
Yitang Li et al.
BLOOD (2009)
Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets
Ilaria Canobbio et al.
BLOOD (2009)
Bipolar disorder and mechanisms of action of mood stabilizers
Stanley I. Rapoport et al.
BRAIN RESEARCH REVIEWS (2009)
Tumor Suppression by Phospholipase C-β3 via SHP-1-Mediated Dephosphorylation of Stat5
Wenbin Xiao et al.
CANCER CELL (2009)
Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
Bijay S. Jaiswal et al.
CANCER CELL (2009)
Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase
Huan Pang et al.
CANCER RESEARCH (2009)
Phospholipase Cε promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis
Mingzhen Li et al.
CARCINOGENESIS (2009)
GOLPH3 Bridges Phosphatidylinositol-4-Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding
Holly C. Dippold et al.
CELL (2009)
Functional Reconstitution of ESCRT-III Assembly and Disassembly
Suraj Saksena et al.
CELL (2009)
The BAR Domain Superfamily: Membrane-Molding Macromolecules
Adam Frost et al.
CELL (2009)
HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes
Kosuke Miyauchi et al.
CELL (2009)
A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication
Andrew W. Tai et al.
CELL HOST & MICROBE (2009)
Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain
Jing Gao et al.
CELLULAR SIGNALLING (2009)
Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness
Wenting Zhu et al.
CIRCULATION RESEARCH (2009)
Small Molecule Inhibitors of Phosphoinositide 3-Kinase (PI3K) delta and gamma
Michael K. Ameriks et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits
Shawn Ferguson et al.
DEVELOPMENTAL CELL (2009)
Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells
Gary M. Pigeau et al.
DIABETES (2009)
Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy
Isabelle Vergne et al.
EMBO JOURNAL (2009)
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
Yuxin Mao et al.
EMBO JOURNAL (2009)
A protein complex that regulates PtdIns(3,5)P2 levels
Robert H. Michell et al.
EMBO JOURNAL (2009)
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
Ivan Ivetac et al.
EMBO REPORTS (2009)
Involvement of nuclear PLCβ1 in lamin B1 phosphorylation and G2/M cell cycle progression
Roberta Fiume et al.
FASEB JOURNAL (2009)
Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening
Maud Trotard et al.
FASEB JOURNAL (2009)
Protein kinase C isoforms: Multi-functional regulators of cell life and death
Mary E. Reyland
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Fine tuning the immune response with PI3K
David A. Fruman et al.
IMMUNOLOGICAL REVIEWS (2009)
A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum
Werner Leber et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY (2009)
MTMR9 Increases MTMR6 Enzyme Activity, Stability, and Role in Apoptosis
Jun Zou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Activity of the Neuronal Cold Sensor TRPM8 Is Regulated by Phospholipase C via the Phospholipid Phosphoinositol 4,5-Bisphosphate
Richard L. Daniels et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Ci-VSP Is a Depolarization-activated Phosphatidylinositol-4,5-bisphosphate and Phosphatidylinositol-3,4,5-trisphosphate 5′-Phosphatase
Christian R. Halaszovich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila
Eva Brombacher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides
Marek K. Korzeniowski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Phox Domain of Sorting Nexin 5 Lacks Phosphatidylinositol 3-Phosphate (PtdIns(3)P) Specificity and Preferentially Binds to Phosphatidylinositol 4,5-Bisphosphate (PtdIns(4,5)P2)
Leonardus M. I. Koharudin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Differential Clathrin Binding and Subcellular Localization of OCRL1 Splice Isoforms
Rawshan Choudhury et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Clathrin Regulates the Association of PIPKIγ661 with the AP-2 Adaptor β2 Appendage
James R. Thieman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Identification of myo-Inositol-3-phosphate Synthase Isoforms CHARACTERIZATION, EXPRESSION, AND PUTATIVE ROLE OF A 16-kDa γc ISOFORM
Ratnam S. Seelan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Oxidative Stress Decreases Phosphatidylinositol 4,5-Bisphosphate Levels by Deactivating Phosphatidylinositol-4-phosphate 5-Kinase β in a Syk-dependent Manner
Mark Z. Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Turtles All the Way: Reflections on myo-Inositol
Bernard W. Agranoff
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIα
Barbara Barylko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis
Roberto J. Botelho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Modulation of Sphingolipid Metabolism by the Phosphatidylinositol-4-phosphate Phosphatase Sac1p through Regulation of Phosphatidylinositol in Saccharomyces cerevisiae
Sarah E. Brice et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase GAIN IN INSULIN RESPONSIVENESS THROUGH Sac3 DOWN-REGULATION IN ADIPOCYTES
Ognian C. Ikonomov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations
Katy L. Everett et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals
Xiaoxiang Deng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis
Yuntao S. Mao et al.
JOURNAL OF CELL BIOLOGY (2009)
Reversible binding and rapid diffusion of proteins in complex with inositol lipids serves to coordinate free movement with spatial information
Gerald R. V. Hammond et al.
JOURNAL OF CELL BIOLOGY (2009)
Dual roles for the Drosophila PI 4-kinase Four wheel drive in localizing Rab11 during cytokinesis
Gordon Polevoy et al.
JOURNAL OF CELL BIOLOGY (2009)
PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking
Christopher S. Wood et al.
JOURNAL OF CELL BIOLOGY (2009)
The β- and γ-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells
Lavanya Vasudevan et al.
JOURNAL OF CELL SCIENCE (2009)
No strings attached: the ESCRT machinery in viral budding and cytokinesis
Bethan McDonald et al.
JOURNAL OF CELL SCIENCE (2009)
Crucial role of phosphatidylinositol 4-kinase IIIα in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling
Hui Ma et al.
JOURNAL OF CELL SCIENCE (2009)
Apical trafficking in epithelial cells: signals, clusters and motors
Ora A. Weisz et al.
JOURNAL OF CELL SCIENCE (2009)
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins
Zhanxiang Wang et al.
JOURNAL OF CELL SCIENCE (2009)
Distribution and Neuronal Expression of Phosphatidylinositol Phosphate Kinase IIγ in the Mouse Brain
Jonathan H. Clarke et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2009)
Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis
Zoltan Jakus et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP
Carlos A. Villalba-Galea et al.
JOURNAL OF GENERAL PHYSIOLOGY (2009)
Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation
Bara Sarraj et al.
JOURNAL OF IMMUNOLOGY (2009)
Plant phospholipid signaling: in a nutshell
Teun Munnik et al.
JOURNAL OF LIPID RESEARCH (2009)
The TC10-Exo70 Complex Is Essential for Membrane Expansion and Axonal Specification in Developing Neurons
Sebastian Dupraz et al.
JOURNAL OF NEUROSCIENCE (2009)
Dlg1, Sec8, and Mtmr2 Regulate Membrane Homeostasis in Schwann Cell Myelination
Annalisa Bolis et al.
JOURNAL OF NEUROSCIENCE (2009)
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes
Sohag N. Saleh et al.
JOURNAL OF PHYSIOLOGY-LONDON (2009)
Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication
Jason Borawski et al.
JOURNAL OF VIROLOGY (2009)
Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y- dependent Sorting Motifs in Different Pathways
Maribel Donoso et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles
Karen Newell-Litwa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Enteropathogenic Escherichia coli Subverts Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate upon Epithelial Cell Infection
Hagit Sason et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2
Tom D. Bunney et al.
MOLECULAR CELL (2009)
Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors
Gary Mo et al.
MOLECULAR PAIN (2009)
Phosphatidylinositol (4,5)-Bisphosphate Regulation of N-Methyl-D-aspartate Receptor Channels in Cortical Neurons
Madhuchhanda Mandal et al.
MOLECULAR PHARMACOLOGY (2009)
Membrane scission by the ESCRT-III complex
Thomas Wollert et al.
NATURE (2009)
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis
Jinhua Shen et al.
NATURE CELL BIOLOGY (2009)
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
Yun Zhong et al.
NATURE CELL BIOLOGY (2009)
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Kohichi Matsunaga et al.
NATURE CELL BIOLOGY (2009)
INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
Monique Jacoby et al.
NATURE GENETICS (2009)
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
Stephanie L. Bielas et al.
NATURE GENETICS (2009)
Putting super-resolution fluorescence microscopy to work
Jennifer Lippincott-Schwartz et al.
NATURE METHODS (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKC beta
Mathilde A. Poussin et al.
MICROBIAL PATHOGENESIS (2009)
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
X-T Hu et al.
ONCOGENE (2009)
Cooperation of Mtmr8 with PI3K Regulates Actin Filament Modeling and Muscle Development in Zebrafish
Jie Mei et al.
PLOS ONE (2009)
Nuclear Envelope Remnants: Fluid Membranes Enriched in STEROLS and Polyphosphoinositides
Marie Garnier-Lhomme et al.
PLOS ONE (2009)
Patterned Neuroprotection in the Inpp4awbl Mutant Mouse Cerebellum Correlates with the Expression of Eaat4
Andrew J. Sachs et al.
PLOS ONE (2009)
Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels
Mohamed Trebak et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2009)
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
Meghdad Rahdar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Knockin of mutant PIK3CA activates multiple oncogenic pathways
John P. Gustin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes
Jianping Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110 alpha and are disrupted in oncogenic p85 mutants
Haiyan Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions
Declan J. James et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ
Barbara Kurig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inositol phosphatase SHIP1 is a primary target of miR-155
Ryan M. O'Connell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Specific function of phosphoinositide 3-kinase beta in the control of DNA replication
Miriam Marques et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons
J. Paul Simons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication
Kristi L. Berger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane
Diana Mandelker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mammalian phosphoinositide kinases and phosphatases
Takehiko Sasaki et al.
PROGRESS IN LIPID RESEARCH (2009)
PI3Kγ Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells
Thomas Bohnacker et al.
SCIENCE SIGNALING (2009)
PIKfyve Regulation of Endosome-Linked Pathways
Jane de Lartigue et al.
TRAFFIC (2009)
Regulation of phosphoinositide 3-kinase expression in health and disease
Klaartje Kok et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication
Frederic H. Vaillancourt et al.
VIROLOGY (2009)
Targeting host factors: A novel rationale for the management of hepatitis C virus
Mahmoud Aboelneen Khattab
WORLD JOURNAL OF GASTROENTEROLOGY (2009)
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate
Donghee Kim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma
Mamta Sharma et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
PIP2 is a necessary cofactor for ion channel function: How and why?
Byung-Chang Suh et al.
ANNUAL REVIEW OF BIOPHYSICS (2008)
Dissecting the localization and function of Atg18, Atg21 and Ygr223c
Roswitha Krick et al.
AUTOPHAGY (2008)
Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane
Chao Zhai et al.
BIOCHEMICAL JOURNAL (2008)
Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ
Gwanghyun Jung et al.
BIOCHEMICAL JOURNAL (2008)
The regulation and function of Class III PI3Ks: novel roles for Vps34
Jonathan M. Backer
BIOCHEMICAL JOURNAL (2008)
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes
Roberta E. Redfern et al.
BIOCHEMISTRY (2008)
Activation of human phospholipase C-η2 by Gβγ
Yixing Zhou et al.
BIOCHEMISTRY (2008)
The glycosylphosphatidylinositol anchor: A complex membrane-anchoring structure for proteins
Margot G. Paulick et al.
BIOCHEMISTRY (2008)
Targeting phosphoinositide 3-kinase - Moving towards therapy
Romina Marone et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
Involvement of phosphatidylinositol 4,5-bisphosphate in the desensitization of canonical transient receptor potential 5
Byung Joo Kim et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester
Shuzo Ikuta et al.
CANCER RESEARCH (2008)
Phospholipase Cγ1 Is Required for Metastasis Development and Progression
Gianluca Sala et al.
CANCER RESEARCH (2008)
Portrait of PTEN:: Messages from mutant mice
Akira Suzuki et al.
CANCER SCIENCE (2008)
Structural basis of membrane invagination by F-BAR domains
Adam Frost et al.
CELL (2008)
Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1
Andrew Y. Kim et al.
CELL (2008)
Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate
Loic Lemonnier et al.
CELL CALCIUM (2008)
Amino acids activate mTOR Complex 1 via Ca2+/CaM signaling to hVps34
Pawan Gulati et al.
CELL METABOLISM (2008)
The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole
Curdin Ragaz et al.
CELLULAR MICROBIOLOGY (2008)
Genetic and pharmacological targeting of phosphoinositide 3-kinase-γ reduces atherosclerosis and favors plaque stability by modulating inflammatory processes
Anne Fougerat et al.
CIRCULATION (2008)
Moving towards a better understanding of chemotaxis
Len Stephens et al.
CURRENT BIOLOGY (2008)
An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of CIC-3 Function
Jennifer Mitchell et al.
CURRENT BIOLOGY (2008)
ESCRT complexes and the biogenesis of multivesicular bodies
James H. Hurley
CURRENT OPINION IN CELL BIOLOGY (2008)
Physiologic regulation of the epithelial sodium channel by phosphatidylinositides
Oleh Pochynyuk et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2008)
Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation
David Teis et al.
DEVELOPMENTAL CELL (2008)
Golgi localization of glycosyltransferases requires a Vps74p oligomer
Karl R. Schmitz et al.
DEVELOPMENTAL CELL (2008)
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load
Hesso Farhan et al.
EMBO JOURNAL (2008)
Transient receptor potential channels meet phosphoinositides
Bernd Nilius et al.
EMBO JOURNAL (2008)
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse
Natsuko Jin et al.
EMBO JOURNAL (2008)
A selective PIKfyve inhibitor blocks PtdIns(3,5) P2 production and disrupts endomembrane transport and retroviral budding
Harold B. J. Jefferies et al.
EMBO REPORTS (2008)
Impact of transgenic overexpression of SH2-containing inositol 5′-phosphatase 2 on glucose metabolism and insulin signaling in mice
Syota Kagawa et al.
ENDOCRINOLOGY (2008)
Genotypes and phenotypes of Joubert syndrome and related disorders
Enza Maria Valente et al.
EUROPEAN JOURNAL OF MEDICAL GENETICS (2008)
The extreme C-terminal region of phospholipase Cβ1 determines subcellular localization and function; the b splice variant mediates α1-adrenergic receptor responses in cardiomyocytes
David R. Grubb et al.
FASEB JOURNAL (2008)
Phospholipase C-δ1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development
Yoshikazu Nakamura et al.
FASEB JOURNAL (2008)
Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate
Ken-ichi Otsuguro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate
Matthew W. Bunce et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Phospholipase C-δ1 expression is linked to proliferation, DNA synthesis, and cyclin E levels
Jonathan D. Stallings et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Dual Activation of Phospholipase C-ε by Rho and Ras GTPases
Jason P. Seifert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases
Md. Israil Hossain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels
Baskaran Thyagarajan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Dissociation of Rac1(GDP)•RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, rac guanine nucleotide exchange factor, and GTP
Yelena Ugolev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Rac Regulates Its Effector Phospholipase Cγ2 through Interaction with a Split Pleckstrin Homology Domain
Claudia Walliser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion
Declan J. James et al.
JOURNAL OF CELL BIOLOGY (2008)
Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3
Dan Baird et al.
JOURNAL OF CELL BIOLOGY (2008)
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
Anastasia Blagoveshchenskaya et al.
JOURNAL OF CELL BIOLOGY (2008)
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
Gustavo V. Mallo et al.
JOURNAL OF CELL BIOLOGY (2008)
Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum
Douwe M. Veltman et al.
JOURNAL OF CELL BIOLOGY (2008)
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments
Phyllis I. Hanson et al.
JOURNAL OF CELL BIOLOGY (2008)
The regulation of cell motility and chemotaxis by phospholipid signaling
Verena Kolsch et al.
JOURNAL OF CELL SCIENCE (2008)
Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor
Namiko Abe et al.
JOURNAL OF CELL SCIENCE (2008)
The multiple roles of PtdIns(4)P -: not just the precursor of PtdIns(4,5)P2
Giovanni D'Angelo et al.
JOURNAL OF CELL SCIENCE (2008)
Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes
Deborah Leonard et al.
JOURNAL OF CELL SCIENCE (2008)
Regulation of PLCβ1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate
Merel J. W. Adjobo-Hermans et al.
JOURNAL OF CELL SCIENCE (2008)
Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development
Sook-Young Yoon et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway
Thirumalini Vaithianathan et al.
JOURNAL OF GENERAL PHYSIOLOGY (2008)
Dual functions of Bruton's tyrosine kinase and tec kinase during Fcγ receptor-induced signaling and phagocytosis
Jenny Jongstra-Bilen et al.
JOURNAL OF IMMUNOLOGY (2008)
ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality
Diego Sbrissa et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions
Louis-Philippe Bernier et al.
JOURNAL OF NEUROSCIENCE (2008)
Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes
Anthony P. Albert et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
The PI(3,5)P2 and PI(4,5)P2 Interactomes
Bruno Cadmel et al.
JOURNAL OF PROTEOME RESEARCH (2008)
Hair loss and defective T- and B-Cell function in mice lacking ORAI1
Yousang Gwack et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Increased insulin action in SKIP heterozygous knockout mice
Takeshi Ijuin et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression
Chun-Ju Chang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
The Sac1 phosphoinositide phosphatase regulates golgi membrane morphology and mitotic spindle organization in mammals
Yang Liu et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit
Lars Demmel et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cells
Urszula Golebiewska et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic
Branch Craige et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2 alpha on Neurosecretory Vesicles
Peter J. Wen et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth
Lars Demmel et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIα
Andras Balla et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking
Canhong Cao et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase
Roberto J. Botelho et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Eisuke Itakura et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
General and versatile autoinhibition of PLC Isozymes
Stephanie N. Hicks et al.
MOLECULAR CELL (2008)
Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the Sec14 superfamily
Gabriel Schaaf et al.
MOLECULAR CELL (2008)
Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: Myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain
Roberto Buccafusca et al.
MOLECULAR GENETICS AND METABOLISM (2008)
Phospholipase C mediated modulation of TRPV1 channels
Tibor Rohacs et al.
MOLECULAR NEUROBIOLOGY (2008)
A PtdIns4,5P2-regulatednuclear poly(A) polymerase controls expression of select mRNAs
David L. Mellman et al.
NATURE (2008)
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera et al.
NATURE (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Chengyu Liang et al.
NATURE CELL BIOLOGY (2008)
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils
Bryan Heit et al.
NATURE IMMUNOLOGY (2008)
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A. Engelman et al.
NATURE MEDICINE (2008)
Endosomal sorting and signalling: an emerging role for sorting nexins
Peter J. Cullen
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
From cells to organs: building polarized tissue
David M. Bryant et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Coordinated protein sorting, targeting and distribution in polarized cells
Ira Mellman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
C. B. Knobbe et al.
ONCOGENE (2008)
PI3K pathway alterations in cancer: variations on a theme
T. L. Yuan et al.
ONCOGENE (2008)
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators
Yuji Karashima et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
Sergey V. Voronov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice
Fred L. Robinson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate
Hirohide Iwasaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
Fatemeh Fouladkou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation
Yanfeng Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
Julie Guillermet-Guibert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
PTEN-deficient cancers depend on PIK3CB
Susan Wee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
An integrated genomic analysis of human glioblastoma Multiforme
D. Williams Parsons et al.
SCIENCE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
Elisa Ciraolo et al.
SCIENCE SIGNALING (2008)
SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains
Defne Yarar et al.
TRAFFIC (2008)
Phagosome maturation during the removal of apoptotic cells: receptors lead the way
Zheng Zhou et al.
TRENDS IN CELL BIOLOGY (2008)
Oncogenic signaling of class IPI3K isoforms
A. Denley et al.
ONCOGENE (2008)
C-met must translocate to the nucleus to initiate calcium signals
Dawidson A. Gomes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Cytoskeletal control of vesicle transport and exocytosis in chromaffin cells
J. -M. Trifaro et al.
ACTA PHYSIOLOGICA (2008)
Inositol polyphosphates: a new frontier for regulating gene expression
Abel R. Alcazar-Roman et al.
CHROMOSOMA (2008)
Localization of phosphatidylinositol phosphate kinase IIγ in kidney to a membrane trafficking compartment within specialized cells of the nephron
Jonathan H. Clarke et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)
Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration
C. E. McOmish et al.
MOLECULAR PSYCHIATRY (2008)
Subunit organization and functional transitions in Ci-VSP
Susy C. Kohout et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
Rosa Ana Lacalle et al.
JOURNAL OF CELL BIOLOGY (2007)
The yeast VAP homolog Scs2p has that is correlated a phosphoinositide-binding ability with its activity
Satoshi Kagiwada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals
Meera Mani et al.
NEURON (2007)
Mtmr13/Sbf2-deficient mice: an animal model for CMT4B2
Kristian Tersar et al.
HUMAN MOLECULAR GENETICS (2007)
Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase:: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3-mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup
Kristy A. Horan et al.
BLOOD (2007)
The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations
Chuan-Hsiang Huang et al.
SCIENCE (2007)
SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment
Colin J. Traer et al.
NATURE CELL BIOLOGY (2007)
Regulation of ion transport proteins by membrane phosphoinositides
Nikita Gamper et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway
Catrin Williams et al.
JOURNAL OF CELL SCIENCE (2007)
Characterization of a novel tumor-suppressor gene PLCδ1 at 3p22 in Esophageal squamous cell carcinoma
Li Fu et al.
CANCER RESEARCH (2007)
rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells
Yiyuan Yuan et al.
CELL RESEARCH (2007)
Growth control of golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase
Frank Faulhammer et al.
TRAFFIC (2007)
Atg18 regulates organelle morphology and Fab1kinase activity independent of its membrane recruitment by pho sphatidylinositol 3,5-bisphosphate
Jem A. Efe et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
Yanling Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Type I phosphatidylinositol-4, 5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
Jun Zou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes
Lisa J. Kobrynski et al.
LANCET (2007)
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2
Ian H. Batty et al.
BIOCHEMICAL JOURNAL (2007)
Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 complex
Peter Varnai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
Yoshinori Takahashi et al.
NATURE CELL BIOLOGY (2007)
Regulation of transient receptor potential (TRP) channels by phosphoinositides
Tibor Rohacs et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Molecular determinants of PI(4,5)P2 and PI(3,4,5)P3 regulation of the epithelial Na+ channel
Oleh Pochynyuk et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells
Javier Pizarro-Cerda et al.
CELLULAR MICROBIOLOGY (2007)
The lipid connection-regulation of voltage-gated Ca2+ channels by phosphoinositides
Ioannis E. Michailidis et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis
Narae Shin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Phospholipase Cε is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
Simona Citro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The role of phosphoinositide 3-kinase C2α in insulin signaling
Marco Falasca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Depolarization activates the phosphoinositide phosphatase GNP, as detected in Xenopus oocytes coexpressing sensors of PIP2
Yoshimichi Murata et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Small-molecule agonists of SHEP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells
Christopher J. Ong et al.
BLOOD (2007)
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide
Giovanni D'Angelo et al.
NATURE (2007)
Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKIγ of the phophatidylinsitol pathway
Ginat Narkis et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway
Kai S. Erdmann et al.
DEVELOPMENTAL CELL (2007)
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension
Ana Carolina Braga Marcano et al.
JOURNAL OF MEDICAL GENETICS (2007)
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport - Novel sac phosphatase joins the arpikfyve-pikfyve complex
Diego Sbrissa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Phospholipase Cβ is critical for T cell chemotaxis
Tami L. Bach et al.
JOURNAL OF IMMUNOLOGY (2007)
MptpB, a virulence factor from Mycobacterium tublerculosis, exhibits triple-specificity phosphatase activity
Nicola Beresford et al.
BIOCHEMICAL JOURNAL (2007)
Phospholipase C β3 is a key component in the Gβγ/PKCη/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
Alberto M. Diaz Anel
BIOCHEMICAL JOURNAL (2007)
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
Ivette Hernandez-Negrete et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain
Leticia Odriozola et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Dual control of cardiac Na+-Ca2+ exchange by PIP2:: electrophysiological analysis of direct and indirect mechanisms
Alp Yaradanakul et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
The pathologies associated with functional titration of phosphatidylinositol transfer protein a activity in mice
James G. Alb et al.
JOURNAL OF LIPID RESEARCH (2007)
Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIγ regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions
T. Y. El Sayegh et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes
Canhong Cao et al.
TRAFFIC (2007)
Human WIPI-1 puncta-formation: A novel assay to assess mammalian autophagy
Tassula Proikas-Cezanne et al.
FEBS LETTERS (2007)
Type Iγ phosphaticlylinositol phosphate kinase is required for EGF-stimulated directional cell migration
Yue Sun et al.
JOURNAL OF CELL BIOLOGY (2007)
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
Nabil Miled et al.
SCIENCE (2007)
PIP5KIγ is required for cardiovascular and neuronal development
Yanfeng Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
Clement Y. Chow et al.
NATURE (2007)
SNX9 couples actin assembly to Phosphoinositide signals and is required for membrane remodeling during endocytosis
Defne Yarar et al.
DEVELOPMENTAL CELL (2007)
PIP promotes the recruitment of the GGA adaptor proteins to the trans-Golgi TS recognition of the ubiquitin network and regulates their sorting signal
Jing Wang et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Differential redox regulation within the PTP superfamily
Sarah H. Ross et al.
CELLULAR SIGNALLING (2007)
Identification of secretory granule phosphatidylinositol 4,5-bisphosphateinteracting proteins using an affinity pulldown strategy
Shona L. Osborne et al.
MOLECULAR & CELLULAR PROTEOMICS (2007)
Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes
Lynn A. Kamen et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
The nuclear envelope and transcriptional control
Asifa Akhtar et al.
NATURE REVIEWS GENETICS (2007)
Dual regulation of TRPV1 by phosphoinositides
Viktor Lukacs et al.
JOURNAL OF NEUROSCIENCE (2007)
Active genes at the nuclear pore complex
Angela Taddei
CURRENT OPINION IN CELL BIOLOGY (2007)
Replication of hepatitis C virus
Darius Moradpour et al.
NATURE REVIEWS MICROBIOLOGY (2007)
Binding of Ras to phosphoinositide 3-kinase p110α is required for Ras-driven tumorigenesis in mice
Surbhi Gupta et al.
CELL (2007)
Biochemical and biological functions of class I phosphatidylinositol transfer proteins
Shamshad Cockcroft et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling
Ineke Keizer-Gunnink et al.
JOURNAL OF CELL BIOLOGY (2007)
Lack of phospholipase C-δ1 induces skin inflammation
Manabu Ichinohe et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through α-actinin
Ioannis E. Michailidis et al.
JOURNAL OF NEUROSCIENCE (2007)
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
James D. Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Barbara Geering et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer
Michael S. Kostelansky et al.
CELL (2007)
Chemotaxis in the absence of PIP3 gradients
Oliver Hoeller et al.
CURRENT BIOLOGY (2007)
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium
Kosuke Takeda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish
Macie B. Walker et al.
DEVELOPMENTAL BIOLOGY (2007)
Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth
Sonia Severin et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The molecular choreography of a store-operated calcium channel
Richard S. Lewis
NATURE (2007)
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate
Roberto Zoncu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6
Young Kwon et al.
MOLECULAR CELL (2007)
Epac-mediated activation of phospholipase Cε plays a critical role in 6-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
Emily A. Oestreich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Role of activation of PIP5Kγ661 by AP-2 complex in synaptic vesicle endocytosis
Akiko Nakano-Kobayashi et al.
EMBO JOURNAL (2007)
Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells
Eeva Auvinen et al.
EXPERIMENTAL CELL RESEARCH (2007)
Phosholipase C-related inactive protein is involved in trafficking of γ2 subunit-containing GABAA receptors to the cell surface
Akiko Mizokami et al.
JOURNAL OF NEUROSCIENCE (2007)
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to disabled-2 and PtdIns(4,5)P2
Giulietta Spudich et al.
NATURE CELL BIOLOGY (2007)
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
Natalie Andrew et al.
NATURE CELL BIOLOGY (2007)
Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin
Kun Ling et al.
JOURNAL OF CELL BIOLOGY (2007)
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
Fernando Martin-Belmonte et al.
CELL (2007)
Essential role for nuclear PTEN in maintaining chromosomal integrity
Wen Hong Shen et al.
CELL (2007)
Ubiquitination regulates PTEN nuclear import and tumor suppression
Lloyd C. Trotman et al.
CELL (2007)
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
Xinjiang Wang et al.
CELL (2007)
Activation of TRPM7 channels by phospholipase C-coupled receptor agonists
Michiel Langeslag et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Diacylglycerol, when simplicity becomes complex
Silvia Carrasco et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate
Scott R. Bright et al.
MOLECULAR PHARMACOLOGY (2007)
The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress
Alexes Daquinag et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
IP3 receptor/Ca2+ channel: from discovery to new signaling concepts
Katsuhiko Mikoshiba
JOURNAL OF NEUROCHEMISTRY (2007)
Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues
Alan J. Stewart et al.
NEUROENDOCRINOLOGY (2007)
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
Thomas Strahl et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
RdgB proteins: Functions in lipid homeostasis and signal transduction
Deepti Trivedi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Christian Rommel et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Control of cell polarity and motility by the PtdIns(3,4,5)P-3 phosphatase SHIP1
Miki Nishio et al.
NATURE CELL BIOLOGY (2007)
PI(3)K gamma has an important context-dependent role in neutrophil chemokinesis
G. John Fergus et al.
NATURE CELL BIOLOGY (2007)
The intracellular localisation and mobility of Type Iγ phosphatidylinositol 4P 5-kinase splice variants
Maria-Luisa Giudici et al.
FEBS LETTERS (2006)
Pacemaking by HCN channels requires interaction with phosphoinositides
Gerd Zolles et al.
NEURON (2006)
Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages
Rushika M. Perera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Rapid chemically induced changes of Ptdlns(4,5)P2 gate KCNQ ion channels
Byung-Chang Suh et al.
SCIENCE (2006)
Nucleolar localization of phosphatidylinositol 4-kinase PI4K230 in various mammalian cells
Annamaria Kakuk et al.
CYTOMETRY PART A (2006)
Crystal structure of Rac1 bound to its effector phospholipase C-β2
Mark R. Jezyk et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
Won Do Heo et al.
SCIENCE (2006)
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
Bernward Hinkes et al.
NATURE GENETICS (2006)
Phosphatidylinositol 4-kinase IIIβ regulates the transport of ceramide between the endoplasmic reticulum and Golgi
Balazs Toth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Phospholipase Cβ3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons
Sang-Kyou Han et al.
NEURON (2006)
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells
Peter Varnai et al.
JOURNAL OF CELL BIOLOGY (2006)
Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export
Anna Blumental-Perry et al.
DEVELOPMENTAL CELL (2006)
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
Valerie Tosch et al.
HUMAN MOLECULAR GENETICS (2006)
Gβγs and the Ras binding domain of p110γ are both important regulators of PI(3)Kγ signalling in neutrophils
Sabine Suire et al.
NATURE CELL BIOLOGY (2006)
PI3Kγ inhibition:: towards an 'aspirin of the 21st century'?
Thomas Rueckle et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Regulation of Gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2
Phillip Pian et al.
JOURNAL OF GENERAL PHYSIOLOGY (2006)
Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling
Kristina E. Ile et al.
NATURE CHEMICAL BIOLOGY (2006)
Hypertonic stress increases phosphatidylinositol 4,5-bisphosphate levels by activating PIP5KIβ
Masaya Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels
James D. Brady et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting
N. Fili et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A single amino acid mutation attenuates rundown of voltage-gated calcium channels
Xiao-Guang Zhen et al.
FEBS LETTERS (2006)
Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT
Miyuki Kawano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
Anna C. Rutherford et al.
JOURNAL OF CELL SCIENCE (2006)
Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides
Yuichiro Fujiwara et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities of phospholipase Cζ, a mammalian egg-activating factor
Keiji Kuroda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A role for Ptdlns(4,5)P2 and PIP5Kα in regulating stress-induced apoptosis
Jonathan R. Halstead et al.
CURRENT BIOLOGY (2006)
Imaging intracellular fluorescent proteins at nanometer resolution
Eric Betzig et al.
SCIENCE (2006)
Phosphatidylinositol 3-kinase/protein kinase Q-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene
Ying Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
Tor Erik Rusten et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Nuclear PtdIns5P as a transducer of stress signaling: An in vivo role for PIP4Kbeta
David R. Jones et al.
MOLECULAR CELL (2006)
Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III β protects from dephosphorylation and stabilizes lipid kinase activity
Angelika Hausser et al.
JOURNAL OF CELL SCIENCE (2006)
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells
Ama Gassama-Diagne et al.
NATURE CELL BIOLOGY (2006)
Phosphoinositide 3-kinase C2β regulates cytoskeletal organization and cell migration via Rac-dependent mechanism
Roy M. Katso et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
Noora Hyvola et al.
EMBO JOURNAL (2006)
Stable association between Gαq and phospholipase Cβ1 in living cells
Louisa Dowal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
Akira Hayakawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Modulation of GABAA receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition
Takashi Kanematsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Lipid metabolism and dynamics during phagocytosis
Tony Yeung et al.
CURRENT OPINION IN CELL BIOLOGY (2006)
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation
Mitsuaki Tabuchi et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells
Shekhar Srivastava et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Myotubularin phosphatases: policing 3-phosphoinositides
Fred L. Robinson et al.
TRENDS IN CELL BIOLOGY (2006)
Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane
Anne M. Kong et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
Alexandra Van Keymeulen et al.
JOURNAL OF CELL BIOLOGY (2006)
Type Iγ661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis
Shawn F. Bairstow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Receptor activation alters inner surface potential during phagocytosis
Tony Yeung et al.
SCIENCE (2006)
Systematic analysis of myotubularins:: heteromeric interactions, subcellular localisation and endosome-related functions
Oscar Lorenzo et al.
JOURNAL OF CELL SCIENCE (2006)
Characterization of the murine Inpp4b gene and identification of a novel isoform
Mathieu Ferron et al.
GENE (2006)
Phosphatidylinositol 4-kinases: old enzymes with emerging functions
Andras Balla et al.
TRENDS IN CELL BIOLOGY (2006)
Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity
Shenyuan L. Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The Drosophila phosphatidylinositol transfer protein encoded by vibrator is essential to maintain cleavage-furrow ingression in cytokinesis
Melanie K. Gatt et al.
JOURNAL OF CELL SCIENCE (2006)
Specific and nonspecific membrane-binding determinants cooperate in targeting phosphatidylinositol transfer protein β-isoform to the mammalian trans-golgi network
Scott E. Phillips et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein
Ryan J. Perry et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Gα12/13- and rho-dependent activation of phospholipase C-ε by lysophosphatidic acid and thrombin receptors
Melinda D. Hains et al.
MOLECULAR PHARMACOLOGY (2006)
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
M. Vig et al.
SCIENCE (2006)
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
Zachary A. Knight et al.
CELL (2006)
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
LC Foukas et al.
NATURE (2006)
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis
Harald Schulze et al.
BLOOD (2006)
Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells
Gerald R. V. Hammond et al.
JOURNAL OF CELL SCIENCE (2006)
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
S Feske et al.
NATURE (2006)
Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-δ with the cell cycle
Hitoshi Yagisawa et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2006)
A novel domain suggests a ciliary function for ASPM, a brain size determining gene
CP Ponting
BIOINFORMATICS (2006)
The common inositol-reversible effect of mood stabilizers on neurons does not involve GSK3 inhibition, myo-inositol-1-phosphate synthase or the sodium-dependent myo-inositol transporters
Elena Di Daniel et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2006)
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase γ that is highly expressed in heart and interacts with PDE3B
P Voigt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides
S Raychaudhuri et al.
JOURNAL OF CELL BIOLOGY (2006)
ITAM-mediated tonic signalling through pre-BCR and BCR complexes
JG Monroe
NATURE REVIEWS IMMUNOLOGY (2006)
Phosphoinositide 5-phosphatase Fig4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels
JE Duex et al.
EUKARYOTIC CELL (2006)
A role for the RabA4b effector protein PI-4Kβ1 in polarized expansion of root hair cells in Arabidopsis thaliana
ML Preuss et al.
JOURNAL OF CELL BIOLOGY (2006)
PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection
C Pendaries et al.
EMBO JOURNAL (2006)
Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene
S Barnache et al.
ONCOGENE (2006)
The N-terminus of phosphoinositide 3-kinase-C2β regulates lipid kinase activity and binding to clathrin
M Wheeler et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Faithful expression of GFP from the PLCβ2 promoter in a functional class of taste receptor cells
JW Kim et al.
CHEMICAL SENSES (2006)
Inhibition of a background potassium channel by Gq protein α-subunits
XD Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The Vac 14p-Fig4p complex acts independently of Vac7p and couples PI,5P2 synthesis and turnover
JE Duex et al.
JOURNAL OF CELL BIOLOGY (2006)
Lipid and peptide control of phosphatidylinositol 4-kinase IIα activity on Golgi-endosomal rafts
MG Waugh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2
P Berger et al.
HUMAN MOLECULAR GENETICS (2006)
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate
B Nilius et al.
EMBO JOURNAL (2006)
G-protein-coupled receptor agonists activate endogenous phospholipase Cε and phospholipase Cβ3 in a temporally distinct manner
GG Kelley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
LM Ooms et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor
S Minogue et al.
JOURNAL OF CELL SCIENCE (2006)
Targeting of protein kinase C-ε during Fcγ receptor-dependent phagocytosis requires the εC1B domain and phospholipase C-γ1
KL Cheeseman et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
S Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase
MJ Begley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The class IPITP giotto is required for Drosophila cytokinesis
MG Giansanti et al.
CURRENT BIOLOGY (2006)
The inositol phosphatase SHIP-2 down-regulates FcγR-mediated phagocytosis in murine macrophages independently of SHIP-1
J Ai et al.
BLOOD (2006)
A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling
Zachary A. Knight et al.
CELL (2006)
Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1
S Srivastava et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
RH Michell et al.
TRENDS IN BIOCHEMICAL SCIENCES (2006)
Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia
Tadao Arinami
JOURNAL OF HUMAN GENETICS (2006)
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases
A Ungewickell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
JJ Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus
T Strahl et al.
JOURNAL OF CELL BIOLOGY (2005)
Individual phosphoinositide 3-kinase C2α domain activities independently regulate clathrin function
I Gaidarov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phospholipase C ε modulates β-adrenergic receptor dependent cardiac contraction and inhibits cardiac hypertrophy
H Wang et al.
CIRCULATION RESEARCH (2005)
An animal model for Charcot-Marie-Tooth disease type 4B1
S Bonneick et al.
HUMAN MOLECULAR GENETICS (2005)
Role of phosphoinositide signaling in the control of insulin exocytosis
L Waselle et al.
MOLECULAR ENDOCRINOLOGY (2005)
Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT
M Blaustein et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast
SM Routt et al.
TRAFFIC (2005)
Phospholipase C-δ1 and -δ3 are essential in the trophoblast for placental development
Y Nakamura et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Exploiting the PI3K/AKT pathway for cancer drug discovery
BT Hennessy et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
The class II phosphoinositide 3-kinase C2β is not essential for epidermal differentiation
K Harada et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The class II phosphoinositide 3-kinase PI3K-C2β regulates cell migration by a PtdIns(3)P dependent mechanism
J Domin et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Isozyme-specific stimulation of phospholipase C-γ2 by Rac GTPases
T Piechulek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization
Z Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Molecular cloning and characterization of PLC-η2
YX Zhou et al.
BIOCHEMICAL JOURNAL (2005)
Phosphatidylinositol transfer protein-α in netrin-1-induced PLC signalling and neurite outgrowth
Y Xie et al.
NATURE CELL BIOLOGY (2005)
Presynaptic inhibition via a phospholipase C- and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels
SG Lechner et al.
MOLECULAR PHARMACOLOGY (2005)
PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+
J Lee et al.
JOURNAL OF GENERAL PHYSIOLOGY (2005)
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β
AM Al-Khouri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Association between polymorphism of the SNAP29 gene promoter region and schizophrenia
I Wonodi et al.
SCHIZOPHRENIA RESEARCH (2005)
A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility
FS Chang et al.
JOURNAL OF CELL BIOLOGY (2005)
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase
T Nobukuni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Phosphatidylinositol 3-kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis
FA Meunier et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Coincidence detection in phosphoinositide signaling
JG Carlton et al.
TRENDS IN CELL BIOLOGY (2005)
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
MP Byfield et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-tooth type 4B1 neuropathy with myelin outfoldings
A Bolis et al.
JOURNAL OF NEUROSCIENCE (2005)
The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease
FL Robinson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inositol polyphosphate multikinase is a nuclear P13-kinase with transcriptional regulatory activity
AC Resnick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
PKD2 functions as an epidermal growth factor-activated plasma membrane channel
R Ma et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
DF Barber et al.
NATURE MEDICINE (2005)
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
M Camps et al.
NATURE MEDICINE (2005)
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex
A Hausser et al.
NATURE CELL BIOLOGY (2005)
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
HW Shin et al.
JOURNAL OF CELL BIOLOGY (2005)
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
AM Condliffe et al.
BLOOD (2005)
A novel phospholipase C, PLCη2, is a neuron-specific isozyme
M Nakahara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis
SJ Field et al.
CURRENT BIOLOGY (2005)
PIP2 hydrolysis and calcium release are required for cytokinesis in Drosophila spermatocytes
R Wong et al.
CURRENT BIOLOGY (2005)
Phosphatidylinositol-4-kinase type II α is a component of adaptor protein-3-derived vesicles
G Salazar et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
J Luo et al.
JOURNAL OF CELL BIOLOGY (2005)
Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network
R Choudhury et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic β cells
DJ Pagliarini et al.
MOLECULAR CELL (2005)
Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions
E Mortier et al.
EMBO JOURNAL (2005)
Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic β cells through activation of phosphatidylinositol 4-kinase β
J Gromada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
J Liou et al.
CURRENT BIOLOGY (2005)
The role of the phosphoinositides at the Golgi complex
MA De Matteis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)
VEGF-PLCγ1 pathway controls cardiac contractility in the embryonic heart
W Rottbauer et al.
GENES & DEVELOPMENT (2005)
p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration
V Munugalavadla et al.
BLOOD (2005)
Nuclear phospholipase C: Involvement in signal transduction
L Manzoli et al.
PROGRESS IN LIPID RESEARCH (2005)
Mutations in PIP5K3 are associated with Francois-Neetens Mouchetee fleck corneal dystrophy
SL Li et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2005)
The relative role of PLCβ and PI3Kγ in platelet activation
LR Lian et al.
BLOOD (2005)
Structural basis of FFAT motif-mediated ER targeting
SE Kaiser et al.
STRUCTURE (2005)
Molecular cloning and characterization of a novel phospholipase C, PLC-η
JI Hwang et al.
BIOCHEMICAL JOURNAL (2005)
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
Y Murata et al.
NATURE (2005)
Signaling through Disabled 1 requires phosphoinositide binding
YC Huang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production
JP Frederick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression
J Verbsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Regulation of phospholipase C-δ1 through direct interactions with the small GTPase Ral and calmodulin
RS Sidhu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Nuclear translocation of phospholipase C-δ1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate
JD Stallings et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
T Maffucci et al.
JOURNAL OF CELL BIOLOGY (2005)
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
Y Samuels et al.
CANCER CELL (2005)
Cell wall integrity signaling in Saccharomyces cerevisiae
DE Levin
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2005)
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain
T Slagsvold et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A new tyrosine phosphorylation site in PLCγ1:: The role of tyrosine 775 in immune receptor signaling
CJ Serrano et al.
JOURNAL OF IMMUNOLOGY (2005)
Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions
T Balla
JOURNAL OF CELL SCIENCE (2005)
STIM1, an essential and conserved component of store-operated Ca2+ channel function
J Roos et al.
JOURNAL OF CELL BIOLOGY (2005)
Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast
T Kobayashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Vav activation and function as a Rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis
V Vedham et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-Activated K+ channel KCa3.1
S Srivastava et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
T Rohács et al.
NATURE NEUROSCIENCE (2005)
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3
O Lorenzo et al.
JOURNAL OF CELL SCIENCE (2005)
The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters
K Aoyagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ
C Vecchione et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Nuclear phospholipase C-β1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells
V Lukinovic-Skudar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)
Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes
RD Byrne et al.
BIOCHEMICAL JOURNAL (2005)
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
CC Scott et al.
JOURNAL OF CELL BIOLOGY (2005)
A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins
CJR Loewen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphatidylinositol phosphate kinase type lγ regulates dynamics of large dense-core vesicle fusion
LW Gong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement
SA Brachmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Signalling by PI3K isoforms: insights from gene-targeted mice
B Vanhaesebroeck et al.
TRENDS IN BIOCHEMICAL SCIENCES (2005)
SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis
F Soulet et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels
CMB Lopes et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2
M Fadri et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
p84, a new Gβγ-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110γ
S Suire et al.
CURRENT BIOLOGY (2005)
Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation
G Sidhu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α
J Sasaki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases
KM Weixel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
I Vergne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The receptors and coding logic for bitter taste
KL Mueller et al.
NATURE (2005)
Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells
I Milosevic et al.
JOURNAL OF NEUROSCIENCE (2005)
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase Cε
M Tadano et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha:: Studies with the PH domains of the oxysterol binding protein and FAPP1
A Balla et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function
V Litvak et al.
NATURE CELL BIOLOGY (2005)
Regulation of the interaction between PIPKI-γ and talin by proline-directed protein kinases
SY Lee et al.
JOURNAL OF CELL BIOLOGY (2005)
Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction
R Amarilio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Interaction of neuronal calcium sensor-1 and ADP-ribosylation factor 1 allows bidirectional control of phosphatidylinositol 4-kinase β and trans-Golgi network-plasma membrane traffic
LP Haynes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1
Y Li et al.
MOLECULAR CELL (2005)
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate
BY Liu et al.
JOURNAL OF NEUROSCIENCE (2005)
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
IN Krylova et al.
CELL (2005)
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
MW Sleeman et al.
NATURE MEDICINE (2005)
Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a golgi-specific Ypt31/rab-GTPase signaling pathway
VA Sciorra et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Dent disease with mutations in OCRL1
RR Hoopes et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2005)
The pathway for the production of inositol hexakisphosphate in human cells
JW Verbsky et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p
F Faulhammer et al.
JOURNAL OF CELL BIOLOGY (2005)
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants
SC Sorli et al.
ONCOGENE (2005)
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P
A Godi et al.
NATURE CELL BIOLOGY (2004)
High frequency of mutations of the PIK3CA gene in human cancers
Y Samuels et al.
SCIENCE (2004)
The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate
AC Wild et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
R Takezawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis
M Iijima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ca2+ oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pronucleus during egg activation
A Yoda et al.
DEVELOPMENTAL BIOLOGY (2004)
A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform γ
ML Giudici et al.
BIOCHEMICAL JOURNAL (2004)
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
MNJ Seaman
JOURNAL OF CELL BIOLOGY (2004)
Ca2+ and phosphatidylinositol 4,5-bisphosphate stabilize a Gβγ-sensitive state of CaV2 Ca2+ channels
M Rousset et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
PDK1, the master regulator of AGC kinase signal transduction
A Mora et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)
Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species
CP Downes et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Phosphatidylinositol 4-kinaseβ is critical for functional association of rab11 with the Golgi complex
P de Graaf et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Recombinant phospholipase Cζ has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs
Z Kouchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Genome-wide analysis of membrane targeting by S-cerevisiae pleckstrin homology domains
JW Yu et al.
MOLECULAR CELL (2004)
Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells
H Tronchère et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
M Raftopoulou et al.
SCIENCE (2004)
Hormonal regulation of phospholipase Cε through distinct and overlapping pathways involving G12 and Ras family G-proteins
GG Kelley et al.
BIOCHEMICAL JOURNAL (2004)
Structural basis for endosomal targeting by FYVE domains
A Hayakawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol hexakisphosphate accumulation in yeast
NM Perera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones
M Uldry et al.
EMBO JOURNAL (2004)
Structure-function analysis of phosphatidylinositol transfer protein alpha bound to human phosphatidylinositol
SJ Tilley et al.
STRUCTURE (2004)
BAR domains as sensors of membrane curvature: The amphiphysin BAR structure
BJ Peter et al.
SCIENCE (2004)
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses
SY Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Moving forward: Mechanisms of chemoattractant gradient sensing
J Franca-Koh et al.
PHYSIOLOGY (2004)
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton
A Audhya et al.
EMBO JOURNAL (2004)
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking
G Di Paolo et al.
NATURE (2004)
The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin
A Ungewickell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A PTEN-like phosphatase with a novel substrate specificity
DJ Pagliarini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Modulation of the olfactory CNG channel by Ptdlns(3,4,5)P3
AB Zhainazarov et al.
JOURNAL OF MEMBRANE BIOLOGY (2004)
Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles
J Chua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein
RN Grishanin et al.
NEURON (2004)
Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism
L Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein
M Terunuma et al.
JOURNAL OF NEUROSCIENCE (2004)
PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
E Patrucco et al.
CELL (2004)
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis
AD Hoppe et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Critical role of PIP5KIγ87 in InsP3-mediated Ca2+ signaling
YJ Wang et al.
JOURNAL OF CELL BIOLOGY (2004)
Presence of different phospholipase C isoforms in the nucleus and their activation during compensatory liver growth
V Crljen et al.
FEBS LETTERS (2004)
Mechanism of tyrosine phosphorylation and activation of phospholipase C-γ1 -: Tyrosine 783 phosphorylation is not sufficient for lipase activation
F Sekiya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Phospholipase C δ-type consists of three isozymes:: bovine PLCδ2 is a homologue of human/mouse PLCδ4
Y Irino et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes
U Rescher et al.
JOURNAL OF CELL SCIENCE (2004)
Phosphotidylinositol 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels
N Gamper et al.
JOURNAL OF NEUROSCIENCE (2004)
Protein kinase-independent activation of CFTR by phosphatidylinositol phosphates
B Himmel et al.
EMBO REPORTS (2004)
Polymorphisms in type IISH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome
PJ Kaisaki et al.
DIABETES (2004)
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane
JH Bai et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
J Kwon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis
A Bolino et al.
JOURNAL OF CELL BIOLOGY (2004)
Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells
JJ Collier et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
RhoA activates purified phospholipase C-ε by a guanine nucleotide-dependent mechanism
JP Seifert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
AT Sasaki et al.
JOURNAL OF CELL BIOLOGY (2004)
Salmonella modulates vesicular traffic by altering phosphoinositide metabolism
LD Hernandez et al.
SCIENCE (2004)
ENTH/ANTH proteins and clathrin-mediated membrane budding
V Legendre-Guillemin et al.
JOURNAL OF CELL SCIENCE (2004)
Genetic evidence of a role for membrane lipid composition in the regulation of soluble NEM-sensitive factor receptor function in Saccharomyces cerevisiae
A Coluccio et al.
GENETICS (2004)
The pleckstrin homology domain of phosphoinositide-specific phospholipase Cδ4 is not a critical determinant of the membrane localization of the enzyme
SB Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The phox homology (PX) domain protein interaction network in yeast
CS Vollert et al.
MOLECULAR & CELLULAR PROTEOMICS (2004)
Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals
MR Wenk et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Critical role of mast cells in inflammatory diseases and the effect of acute stress
TC Theoharides et al.
JOURNAL OF NEUROIMMUNOLOGY (2004)
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways
LK MacDougall et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
P50 alpha/p55 alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
D Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Subversion of phosphoinositide metabolism by intracellular bacterial pathogens
J Pizarro-Cerdá et al.
NATURE CELL BIOLOGY (2004)
Pleckstrin homology domains: not just for phosphoinositides
MA Lemmon
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Vacuole size control: Regulation of PtdIns(3,5)P-2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3.5)P-2-specific phosphatase
SA Rudge et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-γ2
YJ Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase β-/- mice
KA Lamia et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49
TR Jeffries et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides
J Carlton et al.
CURRENT BIOLOGY (2004)
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe synaptojanin and SHIP2
YL Chi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p
A Roy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
K Ali et al.
NATURE (2004)
Chemoattractant signaling in Dictyostelium discoideum
CL Manahan et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)
Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells
David W. Leung et al.
MOLECULAR CANCER (2004)
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates
D Komander et al.
EMBO JOURNAL (2004)
Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation
AC Schmid et al.
FEBS LETTERS (2004)
Enhanced T cell proliferation in mice lacking the p85β subunit of phosphoinositide 3-kinase
JA Deane et al.
JOURNAL OF IMMUNOLOGY (2004)
Direct activation of the epithelial Na+ channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase
QS Tong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
SK Dove et al.
EMBO JOURNAL (2004)
Oxysterols and oxysterol binding proteins: role in lipid metabolism and atherosclerosis
VM Olkkonen et al.
ANNALS OF MEDICINE (2004)
Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain
GT Berry et al.
MOLECULAR GENETICS AND METABOLISM (2004)
The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex
HM Rohde et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The TPTE gene family:: cellular expression, subcellular localization and alternative splicing
C Tapparel et al.
GENE (2003)
Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch
K Ling et al.
JOURNAL OF CELL BIOLOGY (2003)
Molecular machinery for non-vesicular trafficking of ceramide
K Hanada et al.
NATURE (2003)
Class III phosphoinositide 3-kinase-Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes
A Tassa et al.
BIOCHEMICAL JOURNAL (2003)
Intracellular Call and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
D Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Crystal structure of a phosphoinositide phosphatase, MTMR2: Insights into myotubular myopathy and Charcot-Marie-Tooth syndrome
MJ Begley et al.
MOLECULAR CELL (2003)
Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin
J Kwik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila
HC Wei et al.
CURRENT BIOLOGY (2003)
Phosphoinositide 3-kinase γ-deficient mice are protected from isoproterenol-induced heart failure
GY Oudit et al.
CIRCULATION (2003)
Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases
J Laporte et al.
HUMAN MOLECULAR GENETICS (2003)
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
NR Leslie et al.
EMBO JOURNAL (2003)
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization
P Whitley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling
K Takenaka et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Calmodulin-dependent regulation of a lipid binding domain in the v-SNARE synaptobrevin and its role in vesicular fusion
L De Haro et al.
BIOLOGY OF THE CELL (2003)
Crystal structures of the DAB homology domains of mouse disabled 1 and 2
M Yun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns (3,4,5)P3 interactions
HBR Luo et al.
CELL (2003)
The schizophrenia phenotype in 22q11 deletion syndrome
AS Bassett et al.
AMERICAN JOURNAL OF PSYCHIATRY (2003)
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes
RS Jope
TRENDS IN PHARMACOLOGICAL SCIENCES (2003)
Mice lacking phosphatidylinositol transfer protein-α exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia
JG Alb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation
V Carricaburu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
Y Mochizuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Phosphatidylinositol phosphate 5-kinase Iβ recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis
D Padrón et al.
JOURNAL OF CELL BIOLOGY (2003)
Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
T Maffucci et al.
EMBO JOURNAL (2003)
Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase
A Audhya et al.
EMBO JOURNAL (2003)
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the golgi
YJ Wang et al.
CELL (2003)
Vps27 recruits ESCRT machinery to endosomes during MVB sorting
DJ Katzmann et al.
JOURNAL OF CELL BIOLOGY (2003)
Protein sorting into multivesicular endosomes
C Raiborg et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Nuclear speckles: A model for nuclear organelles
AI Lamond et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Neuronal calcium sensor-1: a multifunctional regulator of secretion
S Hilfiker
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
HH Nandurkar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Phosphatidylinositol phosphate kinases put PI4,5P2 in its place
RL Doughman et al.
JOURNAL OF MEMBRANE BIOLOGY (2003)
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
O Gozani et al.
CELL (2003)
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ
M Krauss et al.
JOURNAL OF CELL BIOLOGY (2003)
Phosphoinositide 3-kinase-dependent activation of Rac
HCE Welch et al.
FEBS LETTERS (2003)
Association between Val108/158 met polymorphism of the COMT gene and schizophrenia
I Wonodi et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2003)
Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum
MG Waugh et al.
BIOCHEMICAL JOURNAL (2003)
Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry
MR Wenk et al.
NATURE BIOTECHNOLOGY (2003)
20 years of Ins(1,4,5)P3, and 40 years before
RF Irvine
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Membrane-binding and activation mechanism of PTEN
S Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
On the mechanism of activation of the plasma membrane Ca2+-ATPase by ATP and acidic phospholipids
CV Filomatori et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
TNF-α and leptin activate the α-isoform of class II phosphoinositide 3-kinase
C Ktori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Phospholipase Cδ1 is required for skin stem cell lineage commitment
Y Nakamura et al.
EMBO JOURNAL (2003)
The pleckstrin homology domain of phospholipase C-β2 as an effector site for Rac
JT Snyder et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
phospholipase C gamma-1 is require downstream of vascular endothelial growth factor during arterial development
ND Lawson et al.
GENES & DEVELOPMENT (2003)
Regulation of neuronal SNARE assembly by the membrane
DH Kweon et al.
NATURE STRUCTURAL BIOLOGY (2003)
Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea
GT Berry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Recruitment and activation of phospholipase Cγ1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells
RD Meyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio
L Rodríguez-Borlado et al.
JOURNAL OF IMMUNOLOGY (2003)
Comparison of FcεRI- and FcγRI-mediated degranulation and TNF-α synthesis in human mast cells:: selective utilization of phosphatidylinositol-3-kinase for FcγRi-induced degranulation
Y Okayama et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids
G McConnachie et al.
BIOCHEMICAL JOURNAL (2003)
Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma
H Azzedine et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2003)
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells
YE Huang et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
W Echevarria et al.
NATURE CELL BIOLOGY (2003)
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells
HL Olsen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis
N Rusk et al.
CURRENT BIOLOGY (2003)
Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase
SN Shelton et al.
BIOCHEMICAL JOURNAL (2003)
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase
SA Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm
K Fukami et al.
JOURNAL OF CELL BIOLOGY (2003)
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes
KG Bache et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The synaptojanin-like protein Inp53/Sj13 functions with clathrin in a yeast TGN-to-endosome pathway distinct from the GGA protein-dependent pathway
SA Ha et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization - The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation
R Gurung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
PIP2 activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents
HL Zhang et al.
NEURON (2003)
Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases
J Schaletzky et al.
CURRENT BIOLOGY (2003)
Rac2 regulation of phospholipase C-β2 activity and mode of membrane interactions in intact cells
D Illenberger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet α-granule secretion
N Rozenvayn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLC-γ2
O Inoue et al.
JOURNAL OF CELL BIOLOGY (2003)
Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex
EP Lei et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1
IG Huttner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
YF Zhang et al.
CELL (2003)
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
S Srinivasan et al.
JOURNAL OF CELL BIOLOGY (2003)
Phosphoinositide 3-kinase γ:: a key modulator in inflammation and allergy
MP Wymann et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15
J Senderek et al.
HUMAN MOLECULAR GENETICS (2003)
SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation
T Ijuin et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Mammalian phosphatidylinositol 4-kinases
LMG Heilmeyer et al.
IUBMB LIFE (2003)
Specificity of activation by phosphoinositides determines lipid regulation of Kir channels
T Rohács et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
K Ashrafi et al.
NATURE (2003)
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1
M Innocenti et al.
JOURNAL OF CELL BIOLOGY (2003)
Regulation of chromatin remodeling by inositol polyphosphates
DJ Steger et al.
SCIENCE (2003)
PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis
OC Ikonomov et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs
R Singh et al.
MOLECULAR MICROBIOLOGY (2003)
Phosphoinositide regulation of the actin cytoskeleton
HL Yin et al.
ANNUAL REVIEW OF PHYSIOLOGY (2003)
Regulation of TRP channels via lipid second messengers
RC Hardie
ANNUAL REVIEW OF PHYSIOLOGY (2003)
Dynamics of phosphoinositides in membrane retrieval and insertion
MP Czech
ANNUAL REVIEW OF PHYSIOLOGY (2003)
Pten dose dictates cancer progression in the prostate
LC Trotman et al.
PLOS BIOLOGY (2003)
Polymorphism screening of PIK4CA: Possible candidate gene for chromosome 22q11-linked psychiatric disorders
T Saito et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2003)
Rheb fills a GAP between TSC and TOR
BD Manning et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Distinct monoubiquitin signals in receptor endocytosis
K Haglund et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice
WT Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
A role for PKC-ε in FcγR-mediated phagocytosis by RAW 264.7 cells
EC Larsen et al.
JOURNAL OF CELL BIOLOGY (2002)
The Phox Homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation
GE Cozier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Endocytosed transferrin receptors recycle via distinct dynamin and phosphatidylinositol 3-kinase-dependent pathways
EM van Dam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery
SK Mishra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity
GS Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The deficiency of PIP2 5-phosphatase in Lowe syndrome affects actin polymerization
SF Suchy et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
Essential, nonredundant role for the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex
ST Jou et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Type II phosphatidylinositol 4-kinase β is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP
YJ Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε
CH Song et al.
ONCOGENE (2002)
Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II
B Barylko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Iα impairs localized actin remodeling and suppresses phagocytosis
MG Coppolino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice
A Buj-Bello et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin
G Di Paolo et al.
NATURE (2002)
Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
K Ling et al.
NATURE (2002)
Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2
L Wu et al.
NATURE (2002)
Multiple roles of pleckstrin homology domains in phospholipase Cβ function
F Philip et al.
FEBS LETTERS (2002)
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
AR Tee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase
P Burda et al.
JOURNAL OF CELL SCIENCE (2002)
Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion by Salmonella
MR Terebiznik et al.
NATURE CELL BIOLOGY (2002)
Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster
L Seroude et al.
AGING CELL (2002)
Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology
K Niebuhr et al.
EMBO JOURNAL (2002)
Evolution of protein kinase signaling from yeast to man
G Manning et al.
TRENDS IN BIOCHEMICAL SCIENCES (2002)
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
A Arcaro et al.
EMBO JOURNAL (2002)
Identification of a novel Na+/myo-inositol cotransporter
MJ Coady et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation
E Clayton et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor
SK Mishra et al.
EMBO JOURNAL (2002)
Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae
S Desrivières et al.
BIOCHEMICAL JOURNAL (2002)
Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions
JY Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain
V Litvak et al.
CURRENT BIOLOGY (2002)
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
S Takeshita et al.
NATURE MEDICINE (2002)
Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C
B Mueller-Roeber et al.
PLANT PHYSIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
XS Gao et al.
NATURE CELL BIOLOGY (2002)
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy
AE Wurmser et al.
JOURNAL OF CELL BIOLOGY (2002)
Phosphatidylinositol transfer protein β displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin
B Ségui et al.
BIOCHEMICAL JOURNAL (2002)
The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor
W Stockinger et al.
EMBO JOURNAL (2002)
Role of synaptotagmin in Ca2+-triggered exocytosis
WC Tucker et al.
BIOCHEMICAL JOURNAL (2002)
Subcellular localization of phospholipase C isoforms in vascular smooth muscle
EF LaBelle et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis
BC Suh et al.
NEURON (2002)
ESCRT-III: An endosome-associated heterooligomeric protein complex required for MVB sorting
M Babst et al.
DEVELOPMENTAL CELL (2002)
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body
M Babst et al.
DEVELOPMENTAL CELL (2002)
Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains -: Studies on the PH domains of phospholipase C δ1 and p130
P Várnai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development
D Dormann et al.
CURRENT BIOLOGY (2002)
A phosphatidylinositol (4,5)-bisphosphate binding site within μ2-adaptin regulates clathrin-mediated endocytosis
G Rohde et al.
JOURNAL OF CELL BIOLOGY (2002)
Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs
RV Stahelin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evidence for two interaction regions for phosphatidylinositol(4,5)-bisphosphate on mammalian profilin I
P Skare et al.
FEBS LETTERS (2002)
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
OD Weiner et al.
NATURE CELL BIOLOGY (2002)
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
F Wang et al.
NATURE CELL BIOLOGY (2002)
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis
V Litvak et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor
L Hunyady et al.
JOURNAL OF CELL BIOLOGY (2002)
Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1
P Berger et al.
HUMAN MOLECULAR GENETICS (2002)
Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis
RN Grishanin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Reversible inactivation of the tumor suppressor PTEN by H2O2
SR Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Vac14 controls PtdIns(3,5)P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body
SK Dove et al.
CURRENT BIOLOGY (2002)
PIP2-PDZ domain binding controls the association of syntenin with the plasma membrane
P Zimmermann et al.
MOLECULAR CELL (2002)
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
JT Murray et al.
TRAFFIC (2002)
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments
A Balla et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Tumor suppressor PTEN mediates sensing of chemoattractant gradients
M Iijima et al.
CELL (2002)
Stimulation of phospholipase C-ε by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B
S Evellin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Structure of apo-phosphatidylinositol transfer protein α provides insight into membrane association
A Schouten et al.
EMBO JOURNAL (2002)
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
C Raiborg et al.
NATURE CELL BIOLOGY (2002)
Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade
A Audhya et al.
DEVELOPMENTAL CELL (2002)
Sertoli cell vacuolization and abnormal germ cell adhesion in mice deficient in an inositol polyphosphate 5-phosphatase
E Hellsten et al.
BIOLOGY OF REPRODUCTION (2002)
Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components
TP Levine et al.
CURRENT BIOLOGY (2002)
Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates epithelial sodium channel activity in A6 cells
G Yue et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex
XM Li et al.
JOURNAL OF CELL BIOLOGY (2002)
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member
JD Gary et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac
HCE Welch et al.
CELL (2002)
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p
CJ Bonangelino et al.
JOURNAL OF CELL BIOLOGY (2002)
Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
HJ Liao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Anionic phospholipids regulate native and expressed epithelial sodium channel (ENaC)
HP Ma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mechanism of ADP ribosylation factor-stimulated phosphatidylinositol 4,5-bisphosphate synthesis in HL60 cells
A Skippen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
SET-domain proteins of the Su(var)3-9, E(z) and trithorax families
R Alvarez-Venegas et al.
GENE (2002)
New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families
P Roll et al.
GENE (2002)
Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection
C Nasuhoglu et al.
ANALYTICAL BIOCHEMISTRY (2002)
Mutations in the carboxyl-terminal domain of phospholipase C-β1 delineate the dimer interface and a potential Gαq interaction site
O Ilkaeva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease
SA Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
K Ueki et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate
CJ Stefan et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33ING1
A Kuzmichev et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Membrane targeting of C2 domains of phospholipase C-δ isoforms
B Ananthanarayanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Gene expression profiling predicts clinical outcome of breast cancer
LJ van't Veer et al.
NATURE (2002)
Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells
JR Bruns et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Functional organization of the yeast proteome by systematic analysis of protein complexes
AC Gavin et al.
NATURE (2002)
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function
M Laffargue et al.
IMMUNITY (2002)
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q
AU Singer et al.
NATURE STRUCTURAL BIOLOGY (2002)
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
S Krugmann et al.
MOLECULAR CELL (2002)
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function
T Kanematsu et al.
EMBO JOURNAL (2002)
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca2+] elevation signals
K Eto et al.
DIABETES (2002)
Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells
JG Alb et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Identification of yeast cofilin residues specific for actin monomer and PIP2 binding
PJ Ojala et al.
BIOCHEMISTRY (2001)
Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
SA Didichenko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Tyrosine residues in phospholipase Cγ2 essential for the enzyme function in B-cell signaling
R Rodriguez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Disrupted sperm function and fertilin β processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b
E Hellsten et al.
DEVELOPMENTAL BIOLOGY (2001)
Phosphatidylinositol-4-phosphate 5-kinase-1β is essential for epidermal growth factor receptor-mediated endocytosis
MA Barbieri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris
J Guan et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
The murine orthologue of the golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family
M Guipponi et al.
HUMAN GENETICS (2001)
All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate
JW Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals
Y Nemoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A new phospholipase-C - calcium signalling pathway mediated by cyclic AMP and a Rap GTPase
M Schmidt et al.
NATURE CELL BIOLOGY (2001)
Tumour biology - Weakening link to colorectal cancer?
M Barbier et al.
NATURE (2001)
A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice
A Nystuen et al.
NEURON (2001)
Characterization of MTMR3:: an inositol lipid 3-phosphatase with novel substrate specificity
DM Walker et al.
CURRENT BIOLOGY (2001)
PIP kinase 1γ is the major PI(4,5)P2 synthesizing enzyme at the synapse
MR Wenk et al.
NEURON (2001)
A novel mechanism for localizing membrane proteins to yeast trans-Golgi network requires function of synaptojanin-like protein
SA Ha et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
B Kwabi-Addo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
FD Brown et al.
JOURNAL OF CELL BIOLOGY (2001)
Phosphoinositide 3-kinase γ mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes
JF Quignard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain
M Uldry et al.
EMBO JOURNAL (2001)
Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity
HH Nandurkar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Role of the CDC25 homology domain of phospholipase Cε in amplification of Rap1-dependent signaling
TG Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology
M Foti et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
DJ Katzmann et al.
CELL (2001)
Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
D Yablonski et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
SNX3 regulates endosomal function through its PX-domain-mediated interaction with Ptdlns(3)P
Y Xu et al.
NATURE CELL BIOLOGY (2001)
The PX domains of p47phox and p40phox bind to lipid products of Pl(3)K
F Kanai et al.
NATURE CELL BIOLOGY (2001)
Phox domain interaction with Ptdlns(S)P targets the Vam7 t-SNARE to vacuole membranes
ML Cheever et al.
NATURE CELL BIOLOGY (2001)
Phoxy lipids: Revealing PX domains as phosphoinositide binding modules
MJ Wishart et al.
CELL (2001)
Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fcγ receptor-mediated phagocytosis
JG Marshall et al.
JOURNAL OF CELL BIOLOGY (2001)
Identification and characterization of a Sac domain-containing phosphoinositide 5-phosphatase
T Minagawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphatidylinositol 4,5-bisphosphate mediates Ca2+-induced platelet α-granule secretion -: Evidence for type II phosphatidylinositol 5-phosphate 4-kinase function
N Rozenvayn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
HH Chuang et al.
NATURE (2001)
PTEN 2, a Golgi-associated testis-specific homologue or the PTEN tumor suppressor lipid phosphatase
Y Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells
T Takahashi et al.
EMBO JOURNAL (2001)
Phospholipase C-γ mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans
CJ Mitchell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction
TP Levine et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family
S Minogue et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry
LM Broad et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Requirement of phospholipase Cδ4 for the zona pellucida-induced acrosome reaction
K Fukami et al.
SCIENCE (2001)
Specificity determinants in phosphoinositide dephosphorylation: Crystal structure of an archetypal inositol polyphosphate 5-phosphatase
Y Tsujishita et al.
CELL (2001)
FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate
RX Zhao et al.
EXPERIMENTAL CELL RESEARCH (2001)
Mammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatases
CJ O'Malley et al.
BIOCHEMICAL JOURNAL (2001)
Mutations in the 5′ region of the myotubularin-related protein 2 (MTMR2) gene in autosomal recessive hereditary neuropathy with focally folded myelin
H Houlden et al.
BRAIN (2001)
Real time fluorescence imaging of PLCγ translocation and its interaction with the epidermal growth factor receptor
M Matsuda et al.
JOURNAL OF CELL BIOLOGY (2001)
A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation
SL Marcus et al.
FEBS LETTERS (2001)
Human phosphatidylinositol 4-kinase isoform P14K92 - Expression of the recombinant enzyme and determination of multiple phosphorylation sites
S Suer et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans
B Barylko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells
M Yamamoto et al.
JOURNAL OF CELL BIOLOGY (2001)
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5′-phosphatase catalytic activity
T Wada et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
IP3 receptor type 3 and PLCβ2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells
M Asano-Miyoshi et al.
CHEMICAL SENSES (2001)
PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
AJ Hannan et al.
NATURE NEUROSCIENCE (2001)
Phospholipase Cε:: a novel Ras effector
GG Kelley et al.
EMBO JOURNAL (2001)
Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
MGJ Ford et al.
SCIENCE (2001)
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
T Itoh et al.
SCIENCE (2001)
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
A Kihara et al.
JOURNAL OF CELL BIOLOGY (2001)
The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking
I Gaidarov et al.
MOLECULAR CELL (2001)
A novel bifunctional phospholipase C that is regulated by Gα12 and stimulates the Ras/mitogen-activated protein kinase pathway
I Lopez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras
C Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The lipid phosphatase SHIP2 controls insulin sensitivity
S Clément et al.
NATURE (2001)
A regulatory role for src homology 2 domain-containing inositol 5 '-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18)
D Cox et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
The mammalian retinal degeneration B2 gene is not required for photoreceptor function and survival
C Lu et al.
NEUROSCIENCE (2001)
Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanisms
M Estacion et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
The vanilloid receptor: A molecular gateway to the pain pathway
MJ Caterina et al.
ANNUAL REVIEW OF NEUROSCIENCE (2001)
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis
RJ Botelho et al.
JOURNAL OF CELL BIOLOGY (2000)
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
ME Pacold et al.
CELL (2000)
Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1
P Vyas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Accessory factors in clathrin-dependent synaptic vesicle endocytosis
VI Slepnev et al.
NATURE REVIEWS NEUROSCIENCE (2000)
A ubiquitin-like system mediates protein lipidation
Y Ichimura et al.
NATURE (2000)
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation
J Heymont et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity
Y Nemoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis
N Malecz et al.
CURRENT BIOLOGY (2000)
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α
DA Fruman et al.
NATURE GENETICS (2000)
The versatility and universality of calcium signalling
MJ Berridge et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
A role for nuclear phospholipase Cβ1 in cell cycle control
I Faenza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway
F Blondeau et al.
HUMAN MOLECULAR GENETICS (2000)
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate
R Rohatgi et al.
JOURNAL OF CELL BIOLOGY (2000)
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
DJ Gillooly et al.
EMBO JOURNAL (2000)
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
T Sasaki et al.
NATURE (2000)
Overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase, inhibits biosynthetic delivery of an apical protein in polarized Madin-Darby canine kidney cells
OA Weisz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Cloning, and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network
AM Kong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
GS Taylor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Inositol signaling and plant growth (vol 5, pg 252, 2000)
JM Stevenson et al.
TRENDS IN PLANT SCIENCE (2000)
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics
A Audhya et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization
E Kobrinsky et al.
NATURE CELL BIOLOGY (2000)
Intracellular pH regulation by Na+/H+ exchange requires phosphatidylinositol 4,5-bisphosphate
O Aharonovitz et al.
JOURNAL OF CELL BIOLOGY (2000)
Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors
DM Wang et al.
IMMUNITY (2000)
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase
MV Kisseleva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Enzymatic activity of the Src homology 2 domain-containing inositol phosphatase is regulated by a plasma membrane location
H Phee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A pleckstrin homology domain specific for phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2 as being important in exocytosis
RW Holz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
A Arcaro et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Control of intramolecular interactions between the pleckstrin homology and Db1 homology domains of Vav and Sos1 regulates Rac binding
B Das et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The class II phosphoinositide 3-kinase PI3K-C2α is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
J Domin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP3) is an activator of human neutrophil migration
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FEBS LETTERS (2000)
A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Rapid regulated dense-core vesicle exocytosis requires the CAPS protein
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2
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NATURE GENETICS (2000)
Localization of two distinct type III phosphatidylinositol 4-kinase enzyme mRNAs in the rat
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
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CURRENT BIOLOGY (2000)
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control
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SCIENCE (2000)
Interaction of PIP2 with the XIP region of the cardiac Na/Ca exchanger
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)
The multiple roles of PTEN in tumor suppression
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CELL (2000)
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
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SCIENCE (2000)
Localization of the G protein βγ complex in living cells during chemotaxis
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SCIENCE (2000)
Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
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SCIENCE (2000)
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
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SCIENCE (2000)
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
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SCIENCE (2000)
Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene
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ONCOGENE (2000)
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
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MOLECULAR AND CELLULAR BIOLOGY (2000)
Ocrl1, a Ptdlns(4.5)P2 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells
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JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2000)
SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
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EMBO JOURNAL (2000)
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity
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MOLECULAR CELL (2000)
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