4.6 Review

Physiology of Microglia

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Signal Regulatory Protein-β1 A Microglial Modulator of Phagocytosis in Alzheimer's Disease

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Nitric Oxide at the Crossroad of Immunoneuroendocrine Interactions

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Signaling at Purinergic P2X Receptors

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Toll-like receptors in neurodegeneration

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ATP and NO Dually Control Migration of Microglia to Nerve Lesions

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Glutamate induces directed chemotaxis of microglia

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EUROPEAN JOURNAL OF NEUROSCIENCE (2009)

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Microglia and Neuropathic Pain

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IMMUNOLOGICAL REVIEWS (2009)

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Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells

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Enhanced cerebral expression of MCT1 and MCT2 in a rat ischemia model occurs in activated microglial cells

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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Immunology

Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol

Sara Fernandez-Lizarbe et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Immunology

Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression

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JOURNAL OF IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease

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JOURNAL OF MOLECULAR NEUROSCIENCE (2009)

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Activation of P2X(7) receptors induces CCL3 production in microglial cells through transcription factor NFAT

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Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X7 receptor action

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Life and Death of Microglia

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Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

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JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2009)

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Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia

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JOURNAL OF NEUROINFLAMMATION (2009)

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Interleukin-10 and Interleukin-10 Receptor-I Are Upregulated in Glial Cells After an Excitotoxic Injury to the Postnatal Rat Brain

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CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

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Article Neurosciences

Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis

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Article Neurosciences

Morphine Enhances Microglial Migration through Modulation of P2X4 Receptor Signaling

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JOURNAL OF NEUROSCIENCE (2009)

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C1q, the Recognition Subcomponent of the Classical Pathway of Complement, Drives Microglial Activation

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Purinoceptors on Neuroglia

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MOLECULAR NEUROBIOLOGY (2009)

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The Multifaceted Profile of Activated Microglia

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Crystal structure of the ATP-gated P2X4 ion channel in the closed state

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Adenosine A2A receptor mediates microglial process retraction

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Microglial responses to dopamine in a cell culture model of Parkinson's disease

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Role of Ciliary Neurotrophic Factor in Microglial Phagocytosis

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Evidence Group I mGluR Drugs Modulate the Activation Profile of Lipopolysaccharide-Exposed Microglia in Culture

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P2X RECEPTORS AND SYNAPTIC PLASTICITY

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Enlargement of Aβ aggregates through chemokine-dependent microglial clustering

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Endocannabinoid-Mediated Control of Synaptic Transmission

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PHYSIOLOGICAL REVIEWS (2009)

Article Multidisciplinary Sciences

Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis

Deri Morgan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

D. S. Markovic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

The P2X7 receptor-pannexin connection to dye uptake and IL-1β release

Pablo Pelegrin et al.

PURINERGIC SIGNALLING (2009)

Review Cell Biology

Functions and molecular mechanisms of the CD47-SIRPα signalling pathway

Takashi Matozaki et al.

TRENDS IN CELL BIOLOGY (2009)

Review Neurosciences

Purinergic signalling in the nervous system: an overview

Maria P. Abbracchio et al.

TRENDS IN NEUROSCIENCES (2009)

Article Ophthalmology

Regulation of Dynamic Behavior of Retinal Microglia by CX3CR1 Signaling

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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Article Ophthalmology

Nicotinic Acetylcholine Receptor Subunits in Rhesus Monkey Retina

Ji Liu et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Article Biochemistry & Molecular Biology

Hypoxia enhances CXCR4 expression favoring microglia migration via HRF-1α activation

Xubu Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Pharmacology & Pharmacy

Possible involvement of P2X(7) receptor activation in microglial neuroprotection against focal cerebral ischemia in rats

Daijiro Yanagisawa et al.

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Glial toll-like receptor signaling in central nervous system infection and autoimmunity

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BRAIN BEHAVIOR AND IMMUNITY (2008)

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Cellular localization of P2X7 receptor mRNA in the rat brain

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BRAIN RESEARCH (2008)

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Store-operated calcium entry in vascular smooth muscle

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BRITISH JOURNAL OF PHARMACOLOGY (2008)

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Purinergic systems in microglia

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Chloride influx provokes lamellipodium formation in microglial cells

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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2008)

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Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells

Dong Reoyl Seo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2008)

Article Immunology

Toll-like receptors: Insights into their possible role in the pathogenesis of Lyme neuroborreliosis

Andrea L. F. Bernardino et al.

INFECTION AND IMMUNITY (2008)

Article Immunology

Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity

Hua Zi Piao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2008)

Article Immunology

Loss of glycinergic and GABAergic inhibition in chronic pain-contributions of inflammation and microglia

Hanns Ulrich Zeilhofer

INTERNATIONAL IMMUNOPHARMACOLOGY (2008)

Article Ophthalmology

Ex vivo dynamic imaging of retinal microglia using time-lapse confocal microscopy

Jung Eun Lee et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

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Signal Regulatory Proteins (SIRPS) Are Secreted Presynaptic Organizing Molecules

Hisashi Umemori et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse

Adam Denes et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

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Dual role of CD38 in microglial activation and activation-induced cell death

Lior Mayo et al.

JOURNAL OF IMMUNOLOGY (2008)

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Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

Asa Andersson et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

Article Cell Biology

TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis

Amit R. Ashtekar et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

K. Obata et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons

G. Jean Harry et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3

Eiko K. de Jong et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Glial connexins and gap junctions in CNS inflammation and disease

Tammy Kielian

JOURNAL OF NEUROCHEMISTRY (2008)

Article Neurosciences

Neurokinin-1 Receptor Antagonist (Aprepitant) Suppresses HIV-1 Infection of Microglia/Macrophages

Xu Wang et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2008)

Article Immunology

Neuron-microglia signaling: Chemokines as versatile messengers

K. Biber et al.

JOURNAL OF NEUROIMMUNOLOGY (2008)

Article Neurosciences

Resting microglial motility is independent of synaptic plasticity in mammalian brain

Long-Jun Wu et al.

JOURNAL OF NEUROPHYSIOLOGY (2008)

Article Neurosciences

P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury

Hidetoshi Tozaki-Saitoh et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

P2X1 and P2X5 Subunits form the functional P2X receptor in mouse cortical astrocytes

Ulyana Lalo et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia

Rosemary H. Milton et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra

Vikas Kaushal et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia

Yasuhiro Irino et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

Article Pharmacology & Pharmacy

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8

Luciano De Petrocellis et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Editorial Material Neurosciences

A mysterious channel: new insights into proton channel functioning raise new questions

Claudia Eder

JOURNAL OF PHYSIOLOGY-LONDON (2008)

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NLRs and the dangers of pollution and aging

Stephen B. Willingham et al.

NATURE IMMUNOLOGY (2008)

Review Immunology

Chemokines and leukocyte traffic

Federica Sallusto et al.

NATURE IMMUNOLOGY (2008)

Review Genetics & Heredity

Toll-like receptors - taking an evolutionary approach

Francois Leulier et al.

NATURE REVIEWS GENETICS (2008)

Article Endocrinology & Metabolism

Vasoactive intestinal peptide as a healing mediator in Crohn's disease

A. Arranz et al.

NEUROIMMUNOMODULATION (2008)

Article Physiology

New developments in the signaling mechanisms of the store-operated calcium entry pathway

Marie Potier et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)

Review Immunology

From bone marrow to microglia: barriers and avenues

Nathalie Davoust et al.

TRENDS IN IMMUNOLOGY (2008)

Review Neurosciences

Toll-like receptors: roles in neuroprotection?

Uwe-Karsten Hanisch et al.

TRENDS IN NEUROSCIENCES (2008)

Review Neurosciences

Neuronal TRP channels: thermometers, pathfinders and life-savers

Karel Talavera et al.

TRENDS IN NEUROSCIENCES (2008)

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Neuroglia: the 150 years after

Helmut Kettenmann et al.

TRENDS IN NEUROSCIENCES (2008)

Article Medicine, Research & Experimental

Microglia and Astrocyte Activation by Toll-Like Receptor Ligands: Modulation by PPAR-gamma Agonists

Catherine Gurley et al.

PPAR RESEARCH (2008)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Review Ophthalmology

Contribution of TRPV1 to microglia-derived IL-6 and NFκB translocation with elevated hydrostatic pressure

Rebecca M. Sappington et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Neurosciences

Inhibition of toll-like receptor signaling in primary murine microglia

Rajagopal N. Aravalli et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2008)

Review Immunology

How dying cells alert the immune system to danger

Hajime Kono et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

The classical complement cascade mediates CNS synapse elimination

Beth Stevens et al.

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Protease-activated receptors: novel PARtners in innate immunity

V. Shpacovitch et al.

TRENDS IN IMMUNOLOGY (2007)

Article Biochemistry & Molecular Biology

Minocycline decreases in vitro microglial motility, β1-integrin, and Kv1.3 channel expression

Nancy Nutile-McMenemy et al.

JOURNAL OF NEUROCHEMISTRY (2007)

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Toll-like receptors in defense and damage of the central nervous system

Rajagopal N. Aravalli et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2007)

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Aspects of the general biology of adenosine A2A signaling

Bertil B. Fredholm et al.

PROGRESS IN NEUROBIOLOGY (2007)

Article Neurosciences

Notch signaling modulates the activation of microglial cells

Luc Grandbarbe et al.

Article Biochemistry & Molecular Biology

Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

G. C. Brown

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-alpha (TNF-α) regulates Toll-like receptor 2 (TLR2) expression in microglia

Mohsin Md. Syed et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Review Neurosciences

Neuronal 'On' and 'Off' signals control microglia

Knut Biber et al.

TRENDS IN NEUROSCIENCES (2007)

Review Biochemistry & Molecular Biology

The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

Amanda L. Sheldon et al.

NEUROCHEMISTRY INTERNATIONAL (2007)

Article Cell Biology

Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis

Omar S. Qureshi et al.

JOURNAL OF CELL SCIENCE (2007)

Review Neurosciences

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Uwe-Karsten Hanisch et al.

NATURE NEUROSCIENCE (2007)

Article Cell Biology

Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells

Ole H. Petersen et al.

CELL CALCIUM (2007)

Article Immunology

Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia

Seija Lehnardt et al.

JOURNAL OF NEUROIMMUNOLOGY (2007)

Article Neurosciences

Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia

Guillaume Ducharme et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2007)

Review Neurosciences

Neuronal chemokines: Versatile messengers in central nervous system cell interaction

A. H. de Haas et al.

MOLECULAR NEUROBIOLOGY (2007)

Review Biochemistry & Molecular Biology

Na+/Ca2+ exchangers:: three mammalian gene families control Ca2+ transport

Jonathan Lytton

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex

Lynda M. Stuart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Involvement of P2X and P2Y receptors in microglial activation in vivo

H. Franke et al.

PURINERGIC SIGNALLING (2007)

Article Cell Biology

Toll-like receptors modulate adult hippocampal neurogenesis

Asya Rolls et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Modification of neuropathic pain sensation through microglial ATP receptors

Kazuhide Inoue et al.

PURINERGIC SIGNALLING (2007)

Article Neurosciences

CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease

Xi-Jin Wang et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

TLR2 has a detrimental role in mouse transient focal cerebral ischemia

Gina Ziegler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Cell Biology

Regulated ATP release from astrocytes through lysosome exocytosis

Zhijun Zhang et al.

NATURE CELL BIOLOGY (2007)

Article Neurosciences

The microglial networks of the brain and their role in neuronal network plasticity after lesion

Staffan Cullheim et al.

BRAIN RESEARCH REVIEWS (2007)

Review Neurosciences

Neuroprotective role of the innate immune system by microglia

I. Glezer et al.

NEUROSCIENCE (2007)

Article Neurosciences

Regulation of toll-like receptor 4 expression and its signaling by hypoxia in cultured microglia

Jiyeon Ock et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

Article Neurosciences

Reduced axon sprouting after treatment that diminishes microglia accumulation at lesions in the leech CNS

Emmanuel Mbaku Ngu et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2007)

Article Neurosciences

Microglia can be induced by IFN-γ or IL-4 to express neural or dendritic-like markers

Oleg Butovsky et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line

Takato Takenouchi et al.

FEBS LETTERS (2007)

Review Neurosciences

Janus faces of microglia in multiple sclerosis

Patricia Sanders et al.

BRAIN RESEARCH REVIEWS (2007)

Article Neurosciences

WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: Involvement of cannabinoid receptors

R. Bryan Rock et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation

Steven W. Barger et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Purine and pyrimidine receptors

G. Burnstock

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Biochemistry & Molecular Biology

A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity

Donghoon Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Pathology

Microglial recruitment, activation, and proliferation in response to primary demyelination

Leah T. Remington et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

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Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells

Sergei Kirischuk et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)

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Connexin-dependent transcellular transcriptomic networks in mouse brain

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PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2007)

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Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia

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JOURNAL OF NEUROINFLAMMATION (2007)

Article Multidisciplinary Sciences

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Schuichi Koizumi et al.

NATURE (2007)

Review Neurosciences

Understanding LTP in pain pathways

Juergen Sandkuehler

MOLECULAR PAIN (2007)

Article Cell Biology

TheEGF receptor family: spearheading a merger of signaling and therapeutics

Erez M. Bublil et al.

CURRENT OPINION IN CELL BIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke

Javier R. Caso et al.

CIRCULATION (2007)

Article Multidisciplinary Sciences

The molecular choreography of a store-operated calcium channel

Richard S. Lewis

NATURE (2007)

Article Physiology

Quantal release of ATP in mouse cortex

Yuriy Pankratov et al.

JOURNAL OF GENERAL PHYSIOLOGY (2007)

Article Neurosciences

Evidence for synaptic stripping by cortical microglia

Bruce D. Trapp et al.

Article Biochemistry & Molecular Biology

Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide

Anke Osterloh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Neurosciences

Microglial control of neuronal death and synaptic properties

Alain Bessis et al.

Article Immunology

Systemic infections and inflammation affect chronic neurodegeneration

V. Hugh Perry et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Review Neurosciences

The origin and cell lineage of microglia - New concepts

W. Y. Chan et al.

BRAIN RESEARCH REVIEWS (2007)

Review Neurosciences

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Michelle L. Block et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Cell Biology

DAMPs, PAMPs and alarmins: all we need to know about danger

Marco E. Bianchi

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Review Physiology

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Historical review: ATP as a neurotransmitter

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Migration and differentiation of neural precursor cells can be directed by microglia

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P2X7 mediates superoxide production in primary microglia and is up-regulated in a Transgenic mouse model of Alzheimer's disease

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Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-κB interaction in activated microglia

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RA North

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Interferon-γ acutely induces calcium influx in human microglia

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Aquaporin water channels - from atomic structure to clinical medicine

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Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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Trk receptors: mediators of neurotrophin action

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Voltage-gated proton channels in microglia

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Function and spatial distribution of ion channels and transporters in cell migration

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