Leptin and the Central Nervous System Control of Glucose Metabolism

Morton GJ, Schwartz MW. Leptin and the Central Nervous System Control of Glucose Metabolism. Physiol Rev 91: 389-411, 2011; doi:10.1152/physrev.00007.2010.-The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.