期刊
PHYSIOLOGICAL REVIEWS
卷 91, 期 3, 页码 973-1007出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00025.2010
关键词
-
类别
资金
- MICINN [SAF2009-07973]
- Consolider-Ingenio Programme [CSD2007-00017]
- Comunidad de Madrid (OncoCycle Programme) [S-BIO-0283-2006]
- Fundacion Ramon Areces
- Association for International Cancer Research (AICR) [08-0188]
- European Union [HEALTH-F5-2010-241548]
Malumbres M. Physiological Relevance of Cell Cycle Kinases. Physiol Rev 91: 973-1007, 2011; doi: 10.1152/physrev.00025.2010.-The basic biology of the cell division cycle and its control by protein kinases was originally studied through genetic and biochemical studies in yeast and other model organisms. The major regulatory mechanisms identified in this pioneer work are conserved in mammals. However, recent studies in different cell types or genetic models are now providing a new perspective on the function of these major cell cycle regulators in different tissues. Here, we review the physiological relevance of mammalian cell cycle kinases such as cyclin-dependent kinases (Cdks), Aurora and Polo-like kinases, and mitotic checkpoint regulators (Bub1, BubR1, and Mps1) as well as other less-studied enzymes such as Cdc7, Nek proteins, or Mastl and their implications in development, tissue homeostasis, and human disease. Among these functions, the control of self-renewal or asymmetric cell division in stem/progenitor cells and the ability to regenerate injured tissues is a central issue in current research. In addition, many of these proteins play previously unexpected roles in metabolism, cardiovascular function, or neuron biology. The modulation of their enzymatic activity may therefore have multiple therapeutic benefits in human disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据