期刊
PHYSIOLOGICAL MEASUREMENT
卷 35, 期 5, 页码 777-791出版社
IOP PUBLISHING LTD
DOI: 10.1088/0967-3334/35/5/777
关键词
near-infrared spectroscopy; wavelet coherence; phase coherence; functional connectivity; hypertension; cerebral oxygenation; spontaneous oscillations
资金
- National Natural Science Foundation of China [31371002, 11272273, 81071223]
This study aims to assess the prefrontal functional connectivity in elderly subjects with hypertension during the resting state using wavelet coherence analysis of changes in prefrontal tissue oxyhaemoglobin concentrations (Delta [HbO(2)]) signals measured by near-infrared spectroscopy (NIRS). Continuous recordings of NIRS signals were obtained from the left and right prefrontal lobes in 24 elderly subjects with hypertension (age: 70.7 +/- 8.4 years) and 26 elderly normotensive subjects (age: 70.6 +/- 7.9 years) during the resting state. The coherence between the left and right prefrontal oscillations in four frequency intervals (I, 0.4 Hz to 2 Hz; II, 0.15 Hz to 0.4 Hz; III, 0.05 Hz to 0.15 Hz; and IV, 0.02 Hz to 0.05 Hz) was analyzed using wavelet coherence method. The Delta [HbO(2)] oscillations showed significant wavelet coherence (WCO) in intervals I and III, and significant wavelet phase coherence (WPCO) in intervals from I to IV. Remarkably, in elderly subjects with hypertension, theWCO and WPCO in interval III were significantly lower in the left and right prefrontal regions than in healthy elderly subjects (p = 0.014 for WCO, p = 0.007 for WPCO). The lower coherence in interval III indicates a decreased synchronization of neural control in the left and right prefrontal regions in elderly subjects with hypertension. This might suggest a weakened brain functional connectivity in the elderly subjects with hypertension.
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