期刊
PHYSIOLOGICAL GENOMICS
卷 46, 期 1, 页码 17-28出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00085.2013
关键词
beta-defensin; bovine; fertility; immunology
资金
- Irish Department of Agriculture, Food and the Marine [RSF/06340, 11/S/104]
Recent analysis of the bovine genome revealed an expanded suite of beta-defensin genes that encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas primate genomes also encode alpha-and theta-defensins, the bovine genome contains only the beta-defensin subfamily of HDPs. beta-Defensins perform diverse functions that are critical to protection against pathogens but also in regulation of the immune response and reproduction. As the most comprehensively studied subclass of HDPs, beta-defensins possess the widest taxonomic distribution, found in invertebrates as well as plants, indicating an ancient point of origin. Cross-species comparison of the genomic arrangement of beta-defensin gene repertoire revealed them to vary in number among species presumably due to differences in pathogenic selective pressures but also genetic drift. beta-Defensin genes exist in a single cluster in birds, but four gene clusters exist in dog, rat, mouse, and cow. In humans and chimpanzees, one of these clusters is split in two as a result of a primate-specific pericentric inversion producing five gene clusters. A cluster of beta-defensin genes on bovine chromosome 13 has been recently characterized, and full genome sequencing has identified extensive gene copy number variation on chromosome 27. As a result, cattle have the most diverse repertoire of beta-defensin genes so far identified, where four clusters contain at least 57 genes. This expansion of beta-defensin HDPs may hold significant potential for combating infectious diseases and provides opportunities to harness their immunological and reproductive functions in commercial cattle populations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据