期刊
PHYSIOLOGICAL GENOMICS
卷 43, 期 13, 页码 789-798出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00029.2011
关键词
elite athletes; genetics; exercise; genes; polymorphism
资金
- Consejo Superior de Deportes [006/UPR10/11]
- Fondo de Investigaciones Sanitarias [PS09/00194]
Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifying an association between mtDNA variants and aerobic (endurance) exercise phenotypes. The aim of this review is to summarize current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in nonathletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, characterized by maximal oxygen uptake ((V) over dotO(2)max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic backgrounds of the athletic cohorts (Caucasian of mixed geographic origin, Asiatic, or East African).
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