期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 59, 期 7, 页码 1557-1571出版社
IOP Publishing Ltd
DOI: 10.1088/0031-9155/59/7/1557
关键词
x-ray imaging; computed tomography; phase contrast; breast imaging; tissue properties
资金
- DFG Cluster of Excellence Munich-Centre for Advanced Photonics (MAP)
- DFG Gottfried Wilhelm Leibniz program and the European Research Council (ERC) [StG 240142]
X-ray its high capability in visualizing soft tissue. Breast imaging became the focus of particular attention as it is considered the most promising candidate for a first clinical application of this contrast modality. In this study, we investigate quantitative breast tissue characterization using grating-based phase-contrast computed tomography (CT) at conventional polychromatic x-ray sources. Different breast specimens have been scanned at a laboratory phase-contrast imaging setup and were correlated to histopathology. Ascertained tumor types include phylloides tumor, fibroadenoma and infiltrating lobular carcinoma. Identified tissue types comprising adipose, fibroglandular and tumor tissue have been analyzed in terms of phase-contrast Hounsfield units and are compared to high-quality, high-resolution data obtained with monochromatic synchrotron radiation, as well as calculated values based on tabulated tissue properties. The results give a good impression of the method's prospects and limitations for potential tumor detection and the associated demands on such a phase-contrast breast CT system. Furthermore, the evaluated quantitative tissue values serve as a reference for simulations and the design of dedicated phantoms for phase-contrast
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