期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 58, 期 3, 页码 555-568出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/58/3/555
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资金
- Graduate School for Computing in Medicine and Life Sciences
- Germany's Excellence Initiative [DFG GSC 235/1]
- German Research Ministry BMBF [13N9190]
A well-established navigation method is one of the key conditions for successful brain surgery: it should be accurate, safe and online operable. Recent research shows that optical coherence tomography (OCT) is a potential solution for this application by providing a high resolution and small probe dimension. In this study a fiber-based spectral-domain OCT system utilizing a superl-uminescent-diode with the center wavelength of 840 nm providing 14.5 mu m axial resolution was used. A composite 125 mu m diameter detecting probe with a gradient index (GRIN) fiber fused to a single mode fiber was employed. Signals were reconstructed into grayscale images by horizontally aligning A-scans from the same trajectory with different depths. The reconstructed images can display brain morphology along the entire trajectory. For scans of typical white matter, the signals showed a higher reflection of light intensity with lower penetration depth as well as a steeper attenuation rate compared to the scans typical for gray matter. Micro-structures such as axon bundles (70 mu m) in the caudate nucleus are visible in the reconstructed images. This study explores the potential of OCT to be a navigation modality in brain surgery.
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