4.6 Article

Preparation of polymer gel dosimeters based on less toxic monomers and gellan gum

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PHYSICS IN MEDICINE AND BIOLOGY
卷 58, 期 20, 页码 7131-7141

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IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/58/20/7131

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  1. JSPS KAKENHI [23710073]
  2. Grants-in-Aid for Scientific Research [23710073] Funding Source: KAKEN

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New polymer gel dosimeters consisting of 2-hydroxyethyl methacrylate (HEMA), triethylene glycol monoethyl ether monomethacrylate (TGMEMA), polyethylene glycol 400 dimethacrylate (9G), tetrakis (hydroxymethyl) phosphonium chloride as an antioxidant, and gellan gum as a gel matrix were prepared. They were optically analyzed by measuring absorbance to evaluate a dose response. The absorbance of the polymer gel dosimeters that were exposed to Co-60 gamma-rays increased with increasing dose. The dosimeters comprising HEMA and 9G showed a linear increase in absorbance in the dose range from 0 to 10 Gy. The dose response depended on the 9G concentration. For others comprising HEMA, 9G and TGMEMA, the absorbance of the polymer gel dosimeters drastically increased above a certain dose, and then leveled off up to 10 Gy. The optical variations in these polymer gel dosimeters were also induced by x-irradiation from Cyberknife radiotherapy equipment. Furthermore, the exposed region of the latter polymer gel dosimeter exhibited a thermo-responsive behavior.

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