期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 57, 期 23, 页码 7853-7862出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/57/23/7853
关键词
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资金
- Business for Cooperative R&D between Industry, Academy and Research Institute [C0018575]
- Korea Small and Medium Business Administration
- University at Buffalo Clinical and Translational Research Center
- Buffalo Translational Consortium
- Roswell Park Alliance Foundation
- University at Buffalo
We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 mu M. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.
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