期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 56, 期 15, 页码 5063-5077出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/56/15/025
关键词
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资金
- Korea government (MEST) [2010-0020676, 2008-0061772]
- National Research Foundation of Korea [2008-0061772, 2008-2004149] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Spatial smoothing using isotropic Gaussian kernels to remove noise reduces spatial resolution and increases the partial volume effect of functional magnetic resonance images (fMRI), thereby reducing localization power. To minimize these limitations, we propose a novel anisotropic smoothing method for fMRI data. To extract an anisotropic tensor for each voxel of the functional data, we derived an intensity gradient using the distance transformation of the segmented gray matter of the fMRI-coregistered T1-weighted image. The intensity gradient was then used to determine the anisotropic smoothing kernel at each voxel of the fMRI data. Performance evaluations on both real and simulated data showed that the proposed method had 10% higher statistical power and about 20% higher gray matter localization compared to isotropic smoothing and robustness to the registration errors (up to 4 mm translations and 4 degrees rotations) between T1 structural images and fMRI data. The proposed method also showed higher performance than the anisotropic smoothing with diffusion gradients derived from the fMRI intensity data.
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