期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 55, 期 24, 页码 7587-7596出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/55/24/013
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资金
- Research Grants Council of the Hong Kong Government
- Shun Hing Institute of Advanced Engineering, Hong Kong
- 973 Project Fund, China [2010CB732606]
We have previously demonstrated that terahertz pulsed imaging is able to distinguish between rat tissues from different healthy organs. In this paper we report our measurements of healthy and cirrhotic liver tissues using terahertz reflection spectroscopy. The water content of the fresh tissue samples was also measured in order to investigate the correlations between the terahertz properties, water content, structural changes and cirrhosis. Finally, the samples were fixed in formalin to determine whether water was the sole source of image contrast in this study. We found that the cirrhotic tissue had a higher water content and absorption coefficient than the normal tissue and that even after formalin fixing there were significant differences between the normal and cirrhotic tissues' terahertz properties. Our results show that terahertz pulsed imaging can distinguish between healthy and diseased tissue due to differences in absorption originating from both water content and tissue structure.
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