期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 53, 期 21, 页码 6129-6141出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/53/21/016
关键词
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资金
- National Important Science Research Program of China [2006CB933206]
- National Natural Science Foundation of China [60371027, 60171005, 90406023]
- Scientific Research Foundation of Graduate School of Southeast University
We have developed a new type of ultrasound (US) contrast agent, consisting of a gas core, a layer of superparamagnetic iron oxide Fe3O4 nanoparticles (SPIO) and an oil in water outermost layer. The newly developed US contrast agent microbubbles have a mean diameter of 760 nm with a polydisperity index (PI) of 0.699. Our in vitro and in vivo experiments have shown that they have the following advantages compared to gas-encapsulated microbbubbles without SPIO inclusion: (1) they provide better contrast for US images; (2) the SPIO-inclusion microbubbles generate a higher backscattering signal; the mean grey scale is 97.9, which is 38.6 higher than that of microbubbles without SPIO; and ( 3) since SPIO can also serve as a contrast agent of magnetic resonance images (MRI) in vitro, they can be potentially used as contrast agents for double-modality (MRI and US) clinical studies.
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