期刊
VIRUS RESEARCH
卷 210, 期 -, 页码 34-41出版社
ELSEVIER
DOI: 10.1016/j.virusres.2015.07.004
关键词
Type 2 PRRSV; Virulent strain; Full genome; Phylogeny
类别
资金
- University of Minnesota Veterinary Diagnostic Laboratory
- MNDrive Global Food Ventures Fellowship from the state of Minnesota
In early 2014, a Minnesota sow farm with a solid vaccination history suffered a severe porcine reproductive and respiratory syndrome (PRRS) outbreak with unusually high morbidity and mortality in piglets and sows, as well as anorexia and secondary bacterial infections in nursery pigs. Due to the unusual clinical severity in a PRRS-immune herd, genetic characteristics of the virus were examined to determine if a new PRRSV genotype had emerged. Phylogenetic analysis indicated that the virulent strain (PRRSV2/USA/Minnesota414/2014) was related to virulent strains circulating in the mid-western United States in recent years, and that the nonstructural protein 2 (nsp2) gene of MN414 contained an insertion-deletion pattern typical of existing type 2 virulent strains. We conclude that the MN414 isolate is a recently evolved member of the virulent lineage 1 family of type 2 PRRSV. (C) 2015 Elsevier B.V. All rights reserved.
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