期刊
VIROLOGY
卷 485, 期 -, 页码 422-430出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.07.013
关键词
MERS; Middle East Respiratory Syndrome; MERS-CoV; Nonhuman primate; Animal model; Coronavirus
类别
资金
- National Institute of Allergy and Infectious Disease, Division of Intramural Research
- US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-C0V-EMC/2012, MERS-CoV-Jordan-n3/202, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication. Published by Elsevier Inc.
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