期刊
VIROLOGY
卷 483, 期 -, 页码 54-63出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.03.039
关键词
PPRV; V protein; IFN; STAT1; STAT2
类别
资金
- Special Fund for Agro-scientific Research in the Public Interest [201303059]
- National High Technology Research and Development Program (863 program) of China [2011AA10A211]
- earmarked fund for China Agriculture Research System [CARS-40-10]
Peste des petits ruminants virus (PPRV) causes a fatal disease in small ruminants. V protein of PPRV plays a pivotal role in interfering with host innate immunity by blocking IFNs signaling through interacting with STAT1 and STAT2. In the present study, the results demonstrated that PPRV V protein blocks IFN actions in a dose dependent manner and restrains the translocation of STAT1/2 proteins. We speculate that the translocation inhibition might be caused by the interfering of the downstream of STAT protein. Mutagenesis defines that Cys cluster and Trp motif of PPRV V protein are essential for STAT-mediated IFN signaling. These findings give a new sight for the further studies to understand the delicate mechanism of PPRV to escape the IFN signaling. (C) 2015 Elsevier Inc. All rights reserved.
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