期刊
VIROLOGY
卷 476, 期 -, 页码 141-150出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.12.016
关键词
Blebbistatin; Influenza virus assembly; Non-muscle myosin II
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [26860299, 24115002]
- Grants-in-Aid for Scientific Research [24115002, 26860299, 24115001] Funding Source: KAKEN
Actin filaments are known to play a central role in cellular dynamics. After polymerization of actin, various actin-crosslinking proteins including non-muscle myosin II facilitate the formation of spatially organized actin filament networks. The actin-myosin network is highly expanded beneath plasma membrane. The genome of influenza virus (vRNA) replicates in the cell nucleus. Then, newly synthesized vRNAs are nuclear-exported to the cytoplasm as ribonucleoprotein complexes (vRNPs), followed by transport to the beneath plasma membrane where virus particles assemble. Here, we found that, by inhibiting actin-myosin network formation, the virus titer tends to be reduced and HA viral spike protein is aggregated on the plasma membrane. These results indicate that the actin-myosin network plays an important role in the virus formation. (C) 2014 Elsevier Inc. All rights reserved.
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