期刊
VIROLOGY
卷 474, 期 -, 页码 34-40出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.10.019
关键词
HIV-1 genetic diversity; Neutralizing antibody; Next generation sequencing; Neutralizing antibody breadth and potency; Viral evolution
类别
资金
- U.S. Department of Veterans Affairs
- National Institutes of Health [AI090970, AI100665, MH097520, DA034978, AI036214, AI007384, AI047745, AI106039]
- International AIDS Vaccine Initiative (IAVI) [AI090970]
- National Science Foundation [DMS0714991]
- James B. Pendleton Charitable Trust
To better understand the dynamics of HIV-specific neutralizing antibody (NAb), we examined associations between viral genetic diversity and the NAb response against a multi-subtype panel of heterologous viruses in a well-characterized, therapy-naive primary infection cohort. Using next generation sequencing (NGS), we computed sequence-based measures of diversity within HIV-1 env, gag and pal, and compared them to NAb breadth and potency as calculated by a neutralization score. Contemporaneous env diversity and the neutralization score were positively correlated (p=0.0033), as were the neutralization score and estimated duration of infection (EDI) (p=0.0038), and env diversity and EDI (p=0.0005). Neither early env diversity nor baseline viral load correlated with future NAb breadth and potency (p > 0.05). Taken together, it is unlikely that neutralizing capability in our cohort was conditioned on viral diversity, but rather that env evolution was driven by the level of NAb selective pressure. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据