期刊
VIROLOGY
卷 479, 期 -, 页码 52-65出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.02.033
关键词
Antiviral immunity; Type-I interferon; RIG-I-like receptors; Toll-like receptors; cGAS; STING; Ubiquitin; E3 ligases; TRIM proteins; TRIM25
类别
资金
- U.S. National Institutes of Health [AI087846, AI097699, AI104415]
- Alexander and Margaret Stewart Trust Foundation
- John and Virginia Kaneb Fellowship
Ubiquitination has long been known to regulate fundamental cellular processes through the induction of proteasomal degradation of target proteins. More recently, 'atypical' non-degradative types of polyubiquitin chains have been appreciated as important regulatory moieties by modulating the activity or subcellular localization of key signaling proteins. Intriguingly, many of these non-degradative types of ubiquitination regulate the innate sensing pathways initiated by pattern recognition receptors (PRRs), ultimately coordinating an effective antiviral immune response. Here we discuss recent advances in understanding the functional roles of degradative and atypical types of ubiquitination in innate immunity to viral infections, with a specific focus on the signaling pathways triggered by RIG-I-like receptors, Toll-like receptors, and the intracellular viral DNA sensor cGAS. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据