期刊
PHYSICAL REVIEW LETTERS
卷 113, 期 11, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.113.118101
关键词
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资金
- Research Grants Council of the Hong Kong Special Administration Region [HKU 7143/12E, HKU 7147/13E]
- University of Hong Kong [201211159001]
- National Natural Science Foundation of China [11202184]
- Kingboard Endowed Professorship fund
In this work, we developed a method that allows precise control over changes in the size of a cell via hydrostatic pressure changes in the medium. Specifically, we show that a sudden increase, or reduction, in the surrounding pressure, in the physiologically relevant range, triggers cross-membrane fluxes of sodium and potassium ions in leukemia cell lines K562 and HL60, resulting in reversible volumetric deformation with a characteristic time of around 30 min. Interestingly, healthy leukocytes do not respond to pressure shocks, suggesting that the cancer cells may have evolved the ability to adapt to pressure changes in their microenvironment. A model is also proposed to explain the observed cell deformation, which highlights how the apparent viscoelastic response of cells is governed by the microscopic cross-membrane transport.
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