期刊
PHYSICAL REVIEW LETTERS
卷 113, 期 2, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.113.028302
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资金
- Laboratoire d'Excellence Who am I? ( PRES Sorbonne Paris Cite)
- Agence Nationale de la Recherche [ANR-12-NANO-0012]
We directly measure the flow-driven injection of DNA through nanopores at the level of single molecule and single pore using a modified zero-mode waveguide method. We observe a flow threshold independent of the pore radius, the DNA concentration, and length. We demonstrate that the flow injection of DNA in nanopores is controlled by an energy barrier as proposed in the de Gennes-Brochard suction model. Finally, we show that the height of the energy barrier is modulated by functionalizing the nanopores.
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