期刊
PHYSICAL REVIEW LETTERS
卷 112, 期 6, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.112.068101
关键词
-
资金
- National Science Foundation [DMS-0969417, EF-1038636, DGE-0966125]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0969417] Funding Source: National Science Foundation
Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据