期刊
PHYSICAL REVIEW LETTERS
卷 109, 期 15, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.109.158101
关键词
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资金
- Biotechnology and Biological Sciences Research Council
- Frances and Augustus Newman Foundation
- BBSRC [BB/J014346/1, BB/H003843/1] Funding Source: UKRI
- EPSRC [EP/G049998/2, EP/F032773/1] Funding Source: UKRI
- MRC [MC_G1000734] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H003843/1, BB/J014346/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/G049998/2, EP/F032773/1] Funding Source: researchfish
- Medical Research Council [MC_G1000734] Funding Source: researchfish
We study two distinctly ordered condensed phases of polypeptide molecules, amyloid fibrils and amyloidlike microcrystals, and the first-order twisting phase transition between these two states. We derive a single free-energy form which connects both phases. Our model identifies relevant degrees of freedom for describing the collective behavior of supramolecular polypeptide structures, reproduces accurately the results from molecular dynamics simulations as well as from experiments, and sheds light on the uniform nature of the dimensions of different peptide fibrils.
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