期刊
PHYSICAL REVIEW LETTERS
卷 108, 期 26, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.108.268301
关键词
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资金
- EU [236663, 303860]
- MFPL VIPS
- EMBO
- ERC [227758]
- Royal Society
- EPSRC [EP/I001352/1]
- EPSRC [EP/I001352/1, EP/I000844/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I000844/1, EP/I001352/1] Funding Source: researchfish
We present a coarse-grained model of DNA-functionalized colloids that is computationally tractable. Importantly, the model parameters are solely based on experimental data. Using this highly simplified model, we can predict the phase behavior of DNA-functionalized nanocolloids without assuming pairwise additivity of the intercolloidal interactions. Our simulations show that, for nanocolloids, the assumption of pairwise additivity leads to substantial errors in the estimate of the free energy of the crystal phase. We compare our results with available experimental data and find that the simulations predict the correct structure of the solid phase and yield a very good estimate of the melting temperature. Current experimental estimates for the contour length and persistence length of single-stranded (ss) DNA sequences are subject to relatively large uncertainties. Using the best available estimates, we obtain predictions for the crystal lattice constants that are off by a few percent: this indicates that more accurate experimental data on ssDNA are needed to exploit the full power of our coarse-grained approach.
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