期刊
PHYSICAL REVIEW LETTERS
卷 106, 期 24, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.106.248102
关键词
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资金
- Rothschild foundation
- Fulbright foundation
- DOE Office of Science (BER)
- NSF via the CPLC at UIUC [PHY-0822613]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0844670] Funding Source: National Science Foundation
Cells use genetic switches to shift between alternate gene-expression states, e. g., to adapt to new environments or to follow a developmental pathway. Here, we study the dynamics of switching in a generic-feedback on-off switch. Unlike protein-only models, we explicitly account for stochastic fluctuations of mRNA, which have a dramatic impact on switch dynamics. Employing the WKB theory to treat the underlying chemical master equations, we obtain accurate results for the quasistationary distributions of mRNA and protein copy numbers and for the mean switching time, starting from either state. Our analytical results agree well with Monte Carlo simulations. Importantly, one can use the approach to study the effect of varying biological parameters on switch stability.
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