期刊
PHYSICAL REVIEW LETTERS
卷 103, 期 18, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.103.188103
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资金
- Conseil Regional Rhones-Alpes
- Agence Nationale de la Recherche [ANR-06-PCVI-0026, ANR NT05-3-41825]
- Agence Nationale de la Recherche (ANR) [ANR-06-PCVI-0026] Funding Source: Agence Nationale de la Recherche (ANR)
The nucleosome ordering observed in vivo along yeast genes is described by a thermodynamical model of nonuniform fluid of 1D hard rods confined by two excluding energy barriers at gene extremities. For interbarrier distances L less than or similar to 1.5 kbp, nucleosomes equilibrate into a crystal-like configuration with a nucleosome repeat length (NRL) L/n similar to 165 bp, where n is the number of regularly positioned nucleosomes. We also observe bistable'' genes with a fuzzy chromatin resulting from a statistical mixing of two crystal states, one with an expanded chromatin (NRL similar to L/n) and the other with a compact one (NRL similar to L(n + 1)). By means of single nucleosome switching, bistable genes may drastically alter their expression level as suggested by their higher transcriptional plasticity. These results enlighten the role of the intragenic chromatin on gene expression regulation.
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