期刊
PHYSICAL REVIEW LETTERS
卷 103, 期 1, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.103.018101
关键词
-
资金
- National Science Foundation [DMR-0313101]
Previous work has established that protein clusters formed inside the liquid-liquid coexistence envelope can facilitate crystal nucleation. However, recent experiments have indicated the existence of clustering-induced protein nucleation even outside this phase boundary. Here we simulate a minimal model of patchy particles, which are more representative of anisotropic interprotein interactions, and find that transient clusters formed through self-assembly can nucleate crystal growth even under conditions where a dense protein liquid is thermodynamically unstable. The patchy nature of protein interactions thus greatly facilitates their self-assembly, which then guides the subsequent crystal morphology.
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